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Information × Registration Number 0224U033454, (0122U000775) , R & D reports Title Physico-chemical aspects of forming a composite nanostructured biodegradable material for the treatment of damaged peripheral nerves popup.stage_title Медико-біологічні дослідження Head Sukhodub Leonid F., д.ф.-м.н. Registration Date 27-12-2024 Organization Sumy State University popup.description1 Promotion of physicochemical ascpects of biodegradable composite nerve conductors formation, modified by components of different origin (carbon nanoparticles, biologically active substances, proteins, drugs) in the form of tubes or plates and laying the foundation for technological bases of biomaterials with specified functional characteristics , bioactivity, rate of biodegradation, degree of hydration, prolonged drug release, antimicrobial activity popup.description2  The object of research: processes of structural-phase features of forming multicomponent biodegradable materials for use in practical neurosurgery. The goal is to establish the physicochemical regularities of the formation of biodegradable composite nerve conductors modified with components of various origins (carbon nanoparticles, biologically active substances, proteins, drugs). The following was done: A hybrid material for potential use as nerve conductors was synthesized, represented by a chitosan (CS) matrix with homogeneously distributed calcium phosphate particles and impurities of magnetite nanoparticles (Fe3O4), multi-walled carbon nanotubes with Fe content (MWCNT+Fe) and graphene oxide (GO). A multi-stage synthesis technology was developed, which includes a 5-fold freezing process at a temperature of -18°C and thawing (convection at room temperature or under the action of MW (2x60s, 200W) of a colloidal suspension with a Ca/CS ratio = 0.45 and in situ formation of brushite microparticles (DCPD). In vivo studies on the rat models have proven that GO and MWCNTs+Fe-containing composites contribute to nerve regeneration and restoration of limb functions; the in vivo biodegradation period is about 6 months, which indicates the prospects of experimental conduits in the treatment of critical peripheral nerve injuries in humans Product Description popup.authors Kumeda Mariia O. Rebrii Yuliia O. Sukhodub Leonid F. Sukhodub Liudmyla B. Sukhonos Olha V. Tsyndrenko Oleksandr O. popup.nrat_date 2024-12-27 Close