Search academic texts

Information × Registration Number 0224U033564, (0124U003820) , R & D reports Title Nanostructural modification of application drugs for military medical technologies popup.stage_title Дослідження особливостей взаємодії компонентів АЛЗ Head Doroshenko Iryna Yu., Доктор фізико-математичних наук Registration Date 30-12-2024 Organization Taras Shevchenko National University of Kyiv popup.description1 Creation of new-generation modified application drugs, which include wound-healing, anti-inflammatory, antimicrobial and anesthetic ingredients, polymer carriers, excipients with defineddosage and nanostructures, for the treatment of complex wounds after combat trauma and conducting complex physical and pharmacokinetic studies to establish mechanisms of increasing the effectiveness of medicinal products on regeneration processes during wound healing. popup.description2 The project offer a medicinal product for wound healing in the form of an ointment containing substances with antimicrobial (CO2 chamomile extract), anesthetic (lidocaine hydrochloride), anti-inflammatory (ibuprofen), and regenerating, wound-healing (methyl uracil) effects. Polyethylene glycol (PEG-400) is used as a polymer carrier. In addition, it is planned to carry out structural functionalization of drugs by adding antioxidant nanoparticles of silver, graphene oxide and cerium dioxide. In this case, one can also expect the formation of complexes, which will manifest itself in a change in optical properties, the study of which will help to obtain quantitative characteristics of the stability of the complexes and establish the physical nature of binding. The goal of the project is to create modified topical medications of a new generation, which include wound healing, anti-inflammatory, antimicrobial and anesthetic ingredients, polymer carriers, excipients with a defined dosage, and nanostructures, for the treatment of complex wounds after combat trauma. The main tasks are to conduct comprehensive physical and pharmacokinetic studies to establish mechanisms for enhancing the effectiveness of the effects of drugs on regeneration processes during wound healing.  Product Description popup.authors Davtian Lena L. Oksana P. Dmytrenko Drozdova Anna O. Kulish Mykola Р. Lesiuk Andrii I. popup.nrat_date 2024-12-30 Close