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Information × Registration Number 0224U033587, (0123U103004) , R & D reports Title Unordered gold and silver nanostructure arrays for biosensor applications popup.stage_title Дослідження оптичних та морфологічних властивостей розроблених наноструктур золота та срібла в залежності від технологічних режимів виготовлення. Розробка прототипу приладу біосенсора-фотометра для апробації розроблених наночипів в біосенсорних застосуваннях Head Lytvyn Vitalii K., Кандидат технічних наук Registration Date 31-12-2024 Organization V. Lashkarev Institute of Semiconductor Physics of National Academy of Sciences of Ukraine popup.description1 The aim of the work is to optimize the method of fabrication of nanostructure arrays for biosensor applications - sensor sensitive elements (nanochips) based on unordered gold and silver nanostructure arrays popup.description2 Unordered arrays of silver and gold nanostructures were studied using optical spectroscopy and atomic force microscopy. It is shown that optimal morphological and spectral characteristics of silver and gold nanostructures arrays for biosensor applications can be obtained by varying such parameters as effective mass thickness, material of nanoparticles and annealing temperature. Optoelectronic and mechanical blocks for photometer-biosensor prototype were designed and manufactured such as an irradiation module, a two-channel measuring transducer module, a solid-state holder for samples with dimension 13×24×1 mm and standard photometric cuvettes holder. The prototype of the photometer-biosensor device provides optical density (OD) measurement in the range of 0.0001-1.5 with resolution of 0.00005 OD. Developed prototype was used to record a typical biospecific antigen-antibody reaction between bovine serum albumin (BSA) and immunoglobulin IgG (anti-BSA) molecules using gold nanostructure arrays as sensitive elements. It is shown that the change in optical density upon binding of immobilized BSA molecules to antibodies allows the detection of anti-BSA at concentrations of 100 ng/ml. Product Description popup.authors Demydov Petro V. Lytvyn Vitalii K. Khutko Mariia M. popup.nrat_date 2024-12-31 Close