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Registration Number

0225U000114, (0119U101725) , R & D reports

Title

Investigation of the effects of low dose ionizing radiation in natural conditions and model experiments.

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Виконати порівняльний аналіз показників критичних систем організму та рівня дестабілізації геному у тварин за хронічної дії малих доз в модельних експериментах та природних умовах. Провести порівняльний аналіз генотоксичності малих доз радіації in vitro за зовнішнього опромінення та контамінації зразків крові 137Cs.

Head

Lypska Alla I.,

Registration Date

05-01-2025

Organization

Institute for Nuclear Research of NAS of Ukraine

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To investigate the peculiarities of radiation-induced effects of combined and separate internal and external chronic low dose exposure as well as the possibility of their modification, to determine biological efficiency of low dose ionizing radiation of different exposure modes.

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 Comprehensive studies and comparative analysis of the effects of low-dose radiation at the levels of animal body (using reference species from the ChEZ natural populations of murine rodents) and cellular levels (peripheral lymphocytes of human blood) have been conducted. The new experimental data obtained expand the understanding of the biological effectiveness of low-dose radiation and provide a scientific basis for elucidating the mechanisms of medical and biological consequences of chronic irradiation with a significant contribution of the internal component. Experimental models for prolonged external and/or internal in vitro low-dose irradiation of human blood samples to the 137-Cs radioisotope have been created as well as models for absorbed doses calculating.

Product Description

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Bezdrobna Larysa K.
Burdo Olena O.
Hanzha Olena B.
Hrynevych Yuliia P.
Drozd Ivan P.
Zarubina Nataliia Ye.
Kuptsova Liubov I.
Kurochkina Vita A.
Nikolaiev Volodymyr I.
Pavlovskyi Vladyslav V.
Rodionova Nataliia K.
Riabchenko Nataliia M.
Tukalenko Yevhen V.
Fedorchenko Volodymyr I.
Tsyhanok Tetiana V.
Shytiuk Vitalii A.