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Information × Registration Number 0225U000148, (0123U100894) , R & D reports Title Creation of modern calixarene regulators of biochemical processes for medicine and biotechnology. Chapter 1. Investigate bioactive calixarene derivatives as promising regulators of biochemical and biophysical processes for the needs of medicine and biotechnology. popup.stage_title Створення сучасних каліксаренових регуляторів біохімічних процесів для медицини та біотехнології. Розділ 1. Дослідити біоактивні похідні каліксаренів як перспективні регулятори біохімічних та біофізичних процесів для потреб медицини та біотехнології. Head Komisarenko Serhii V., д.б.н. Registration Date 06-01-2025 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description1 Carry out molecular design and synthesis, investigate the properties, biological activity and mechanisms of action of calixarenes - promising regulators of biochemical processes, for medicine and biotechnology. popup.description2 In the field of studying the transmembrane exchange of Ca ions in cells it was shown that 100 μM thiacalix[4]arene C-99 inhibits Na+,K+-ATPase activity in the plasma membranes of myometrial cells. Calix[4]arene C-99 is able to penetrate the plasma membrane. Sulfur-containing thiacalyx[4]arene C-1193 changes the activity of the Ca2+ transport system in mitochondria, effectively suppresses NO synthesis and has a pronounced modulating effect on the functioning of the electron transport chain of myometrial mitochondria. In the field of studying fibrin polymerization, a method of synthesis of compounds of the calix[4]arene series with fixation of the calix[4]arene cup in the "cone" conformation was developed. It turned out that this modification of the structure of molecules leads to the modulation of their biological effects. Calix[4]arene C-145 was also tested for the first time in a rabbit fat embolization model. Effective inhibition of embolization and reduction of pathological activation of the blood coagulation system was observed with the calix[4]arene C-145, which confirms the significant antithrombotic potential of this compound. And, finally, in the field of studying glutamatergic and GABAergic neurotransmission, it was proved that thiacalix[4]arene C-1193 caused depolarization of the synaptosomal membrane and increased the extracellular level of L-[14C]glutamate in nerve terminal preparations. It was shown that the indicated thiacalyx[4]arene increased the extracellular level of [3H]GABA in preparations of nerve terminals. Calix[4]arene C-424 caused depolarization of the synaptosomal membrane and increased the extracellular level of L-[14C]glutamate and [3H]GABA in preparations of nerve terminals, but did not affect the ion conductance of the bilayer membrane. In a fundamental sense, these results expand the current understanding of the mechanisms of macrocyclic compounds action on the most important biochemical processes. Product Description popup.authors Babich Lidiia H. Borysova Tetiana O. Veklich Tetiana O. Danylovych Hanna V. Danylovych Yurii V Karakhim Serhii O. Korolova Daria S. Kosterin Serhii O. Pozdniakova Nataliia H. Chernyshenko Volodymyr O. Chunikhin Oleksandr Yu. Shaturskyi Oleh Ya. Shlykov Serhii H. Yusova Olena I. popup.nrat_date 2025-01-06 Close