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Information × Registration Number 0225U000149, (0122U000139) , R & D reports Title Implementation of the tasks of a promising plan for the development of a scientific direction "Biology and Health" of the Kyiv National University of Technologies and Design. Agreement BF/18-2021 popup.stage_title Виконання завдань перспективного плану розвитку наукового напряму "Біологія та охорона здоров’я" Київського національного університету технологій та дизайну на 2024 рік Head Bessarabov Volodymyr І., Доктор технічних наук Registration Date 06-01-2025 Organization Kyiv National University of Technologies and Design popup.description1 To investigate the properties of the water-ethanol extract of Artemisia Tilesii Ledeb biotechnological vegetation raw materials as a potential 15-lipoxygenase inhibitor popup.description2 In the course of the applied research, the problem of effective polymer composite materials with fungicidal properties, which were specially developed to protect the nail from onychomycosis pathogens, was solved. The obtained results give grounds for asserting that the developed polymer composite materials have pronounced fungicidal properties against the causative agents of onychomycosis. Thanks to the optimal composition, the developed polymer materials have the ability to diffuse into the thickness of the nail. It was established that the membrane of bull hooves is the most similar in properties and chemical composition to the human nail and can be used as a model of the human nail in the study of the fungicidal activity of polymers, as well as the determination of the diffusion of active substances in the thickness of the nail. Pronounced diffusion of active substances into the composition of the nail is explained by the presence of urea in the formulation. Also, the effectiveness of the developed polymer materials is influenced by the fact that cation active surfactants, which were not previously used in antifungal agents, were used as active substances. It is shown that almost all the proposed variants of the polymer composite material with fungicidal action are effective against onychomycosis pathogens, except for the variants that contain polyhexamethylenebiguanide hydrochloride as an active substance. The presented results can be useful in the development of polymer composite materials with fungicidal properties for the prevention and treatment of onychomycosis. The practical application of these results is possible in the production of medical products. Keywords: polymer composite material; varnish with fungicidal properties; nail onychomycosis. Product Description popup.authors Bessarabov Volodymyr I. Kachan Roman V. Kuzmina Halyna I. Lisovyi Vadym M. Lyzhniuk Viktoriia V. popup.nrat_date 2025-01-06 Close