Search academic texts

Information × Registration Number 0225U000216, (0124U000704) , R & D reports Title To develop approaches to the diagnosis of tuberculosis infection and treatment of multidrug-resistant tuberculosis in children in the context of the war in Ukraine and the postwar period popup.stage_title Дослідити епідеміологічну ситуацію щодо туберкульозу та структуру контингенту у дітей різного віку в Україні під час повномасштабної війни Head Bilohortseva Olha I., д.мед.н. Registration Date 07-01-2025 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To develop an algorithm for managing a case of multidrug-resistant tuberculosis in a child, depending on the age and nature of resistance to anti-TB drugs popup.description2  Object of study – 30 children with multidrug-resistant tuberculosis and drug-susceptible tuberculosis, statistical data of the Ministry of Health of Ukraine on TB in children. The aim of the study is to develop an algorithm for the management of multidrug-resistant tuberculosis in children, depending on the age and nature of resistance to anti-TB drugs. Research methods: clinical and radiological, laboratory, statistical. It was found that the incidence of children during the period of full-scale war increased by 1.4 times (up to 10.3 per 100 thousand people of the corresponding age), and adolescents by 1.6 times. The structure of clinical forms of TB has deteriorated due to the increase in the prevalence of MDR+ and destructive forms, drug-resistant TB. The incidence of contact children exceeds the incidence in the population by almost 395 times (in 2021 – 251 times), the incidence of contact adolescents – by 289 times (in 2021 – 124 times). It was determined that localized TB is most often detected in children aged 10-14 years (32.6%) and 5-9 years (26.3%). Pulmonary TB predominates in children of all age groups (72.2-82.6%), bacterial shedding is more common in children under one year old – 47.8% (in 2022 – 70.8%) and adolescents – 49.0% (in 2022 – 52.8%), in children of other ages – 20.3–26.6%. Among extrapulmonary TB, respiratory TB predominates (55.0–74.2%), followed by peripheral lymph node TB, and in children under one year old tuberculosis of the nervous system prevails. The technology of management of children at risk of MDR-TB infection and tuberculosis by timely and thorough examination using modern skin tests with recombinant proteins (ESAT-6 and SFP-10) has been proposed. This contributes to the early detection of TB infection, identification of contingents requiring observation by a pediatric phthisiologist and reducing the risk of local TB in children. Scope of application – tuberculosis, paediatrics, pediatric phthisiology. Product Description popup.authors Bilohortseva Olha I. Dotsenko Yaroslava I. Petishkina Valerii M. Sivachenko Oksana Ye. Firsova Alla S. Shatunova Viktoriia A. Shekhter Iryna Ye. popup.nrat_date 2025-01-07 Close