Search academic texts

Information × Registration Number 0225U000228, (0123U102891) , R & D reports Title Synthesis of model particulate air pollutants (PM) based on silicon dioxide and graphene and development of countermeasures using newly synthesized chelators and sorbents based on functionalized nanoparticles for binding polluting heavy metals and pharmaceuticals popup.stage_title Синтез сорбентів для важких металів шляхом гідроксилювання графеноподібних і кремнеземних наночастинок. Синтез сорбентів для нейроактивних фармацевтичних препаратів шляхом функціоналізації графеноподібних і кремнеземних наночастинок кислотними і основними функціональними групами Head Sotnik Svitlana O., к.х.н. Registration Date 07-01-2025 Organization L. V. Pisarzhevskii Institute Of Physical Chemistry of The National Academy of Sciences of Ukraine popup.description1 The aim is to study the cumulative neurotoxic effects of multicomponent PM pollution and neuroactive pharmaceutical pollutants, biomaterials, toxic metals using a proprietary approach to neurotoxicity assessment using brain nerve terminals, in vitro and in vivo animal models; determination of PM types that can be carriers of pollutants; molecular mechanisms of neurotoxicity; the relationship between PM and susceptibility to SARS-CoV-2; countermeasures. popup.description2  Samples of graphene oxide were synthesized, including those functionalized with carboxyl groups (GO-COOH) and amino groups (GO-NH2), as well as a carbon nanomaterial doped with nitrogen and sulfur heteroatoms (N,S-CNM). Silica particles modified with thiol, sulfate, carboxyl, and amino groups and hydroxylated silica particles were synthesized. The obtained carbon and silica samples can be applied for the sorption of neuroactive pharmaceuticals and heavy metal ions. It was shown that silica particles functionalized with amino groups (MSN-NH2) did not affect the extracellular synaptosomal level of the excitatory neurotransmitter L-[14C]glutamate and, therefore, did not cause excitotoxicity. In fluorescence studies, MSN-NH2 depolarized the membrane, demonstrated weak antioxidant properties, reduced the spontaneous generation of reactive oxygen species, without changing the amount of H2O2 in nerve endings. MSN-NH2 is biocompatible. Hydroxylated silica does not affect the transport of glutamate and gamma-aminobutyric acid even at a final concentration of 1 mg/ml, and also demonstrates the absence of neurotoxicity towards nerve terminals in the rat brain. The sorption of amphotericin, rotenone and oligomycin from saline by a sample of hydroxylated silica was studied. It was found that the sorption capacity of this sample with respect to amphotericin is 3 mmol/g, rotenone 1.7 mmol/g, and oligomycin 9.5 mmol/g. Product Description popup.authors Pariiska Olena O. popup.nrat_date 2025-01-07 Close