Search academic texts

Information × Registration Number 0225U000338, (0123U100390) , R & D reports Title To develop differentiated approaches to the treatment of patients with coronavirus-related lung damage at different stages of the disease popup.stage_title Розробити медичну технологію етіотропної терапії хворих із ураженням легень коронавірусної етіології Head Dziublik Oleksandr Ya., д.мед.н. Registration Date 09-01-2025 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To improve the treatment of patients with coronavirus-related lung damage by differentiated using of etiotropic and pathogenetic therapy at different stages of the disease popup.description2  The object of the study – patients with lesions of the lungs of coronavirus etiology. The aim of the work is to improve the treatment of patients with lung lesions of coronavirus etiology by differentiated use of drugs with etiotropic and pathogenetic effect at different stages of the disease Methods – clinical and radiological, microbiological, statistical. The method of etiotropic therapy of patients with mild severity of Covid-19 and the presence of risk factors for the progression of the disease has been developed and tested. It consists in the combination preferably in the first 5 days of the first clinical manifestations of symptomatic treatment (ST) with additional use of aminocaproic acid (ACA) inhalation through a nebulizer of 2 ml (50 mg/ml) 3 times a day for 7 days. With the help of a multidimensional model of efficiency and safety of treatment of this category of patients it is established that the use of AKC allows to achieve reliably (p <0.05) faster (2-3 days) clinical improvement, to prevent the progression of the disease and to reduce by 20.8 % of the development of undesirable phenomena than other alternative therapeutic strategies – the use of nirmatrelvir/retinovir (N/R) or only ST. Pharmacoeconomic analysis of the profitability of different modes of therapy by the method of "value minimization" indicates the unconditional advantages of the use of AKC inhalation in the treatment of this category of patients which allows for reliable to reduce the cost of treatment due to the low cost of the drug and the short duration of drug therapy due to faster clinical improvement, prevention of disease progression and development of undesirable phenomena. Sphere of application – pulmonology. Product Description popup.authors Bychkova Svitlana A. Bororova Olena L Velychko Olha O. Humeniuk Mykola I. Denysova Olha V. Dziublyk Iryna V. Dziublyk Oleksandr Ya. Diachenko Viktor V. Kapitan Heorhii B. Sukhin Rostyslav Ye. TTrokhymenko Olena P. Yakovenko Oleh K. Yachnyk Vitalii A. popup.nrat_date 2025-01-09 Close