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Information × Registration Number 0225U000358, (0123U102321) , R & D reports Title Experimental substantiation of the development of prophylactic means to prevent metabolic disorders caused by xenobiotics of military origin popup.stage_title Дослідити стан зубощелепної, кісткової та травної систем, а також поведінкові реакції щурів після тривалого введення надлишкових доз хлориду алюмінію Head Makarenko Olha A., Доктор біологічних наук Registration Date 10-01-2025 Organization State Establishment «Institute of Stomatology and Maxillofacial Surgery National Academy of Medical Sciences of Ukraine" popup.description1 To establish the main mechanisms of the pathogenic action of some xenobiotics of military origin on the condition of the maxillofacial, bone and digestive systems of laboratory rats and to develop schemes of preventive measures popup.description2  The object of the study is dental diseases under the influence of xenobiotics of military origin The purpose of the work is to establish the mechanisms of the pathogenetic effect of some toxic substances on the state of the jaw and bone systems of laboratory rats. Research methods are experimental, morphometric, biochemical, statistical. Equipment – ​​spectrophotometer UV mini-1240 Shimadzu, ionometer complete with electrodes ESL-43-07, laboratory scales VLR-200 and electronic analytical balance ESJ-60, centrifuge RS-6. Scientific novelty. Disturbances in the composition and metabolism of the bone tissue of rats with long-term intake of aluminum chloride against the background of a high-sucrose diet or alimentary lipid peroxides were established. In the mucous membrane of the oral cavity, harmful factors caused the development of inflammation and oxidative stress. Long-term intoxication with aluminum led to changes in behavioral reactions in rats, which indicate a violation of memory processes and orientation in space. Prolonged stress reproduced by variable-frequency ultrasound in combination with audible range sound caused liver function disorders in rats: destruction of hepatocytes, cholestasis phenomena, inflammation, disruption of protein-synthetic function, reduction of cholesterol synthesis, oxidative stress. Practical value. The conducted research is a justification for the development and introduction of adaptogens, vitamins, macro- and microelements for the prevention of complications in the dental-jaw, bone and digestive system under the influence of xenobiotics. 10 articles were published (including 3 Scopus), 1 abstract of lectures, 16 theses of reports, 1 technology, 5 reports were made at scientific conferences. Product Description popup.authors Kostiuchenko Liudmyla S. Mudryk Liubov M. Khodak Ihor V. Khromahina Larysa M. popup.nrat_date 2025-01-10 Close