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Information × Registration Number 0225U000414, (0121U108323) , R & D reports Title Synthesis of new nitrogen-, sulfur- and oxygen-containing heterocyclic compounds and study of their practical-useful properties popup.stage_title Синтез нових нітрогено-, сульфуро- та оксигеновмісних гетероциклічних сполук та дослідження їх біологічних та інших практично-корисних властивостей Head Sukhovieiev Volodymyr Volodymyrovych, д.х.н. Registration Date 11-01-2025 Organization Nizhyn Mykola Gogol State University popup.description1 Synthesis of new nitrogen-, sulfur- and oxygen-containing heterocyclic compounds and study of their biological and other practical-useful properties popup.description2 The Chemistry of nitrogen-, sulfur-, and oxygen-containing heterocycles is rapidly developing due to their wide range of practically useful properties, including the creation of new medicines. Among the mentioned heterocyclic systems, particular interest is drawn to compounds containing arylisooxazole, di- or triazacyclopentaazulene, imidazopyridine, imidazotriazepine, 1,3-oxazole, pyrazolothiazolidine, trialolotriazine, pyrimidinetrione, 1,2,4- or 1,3,5-triazine and triazoloazepine cycles, as significant numbers of bio-regulators with various actions have been found within these classes of substances. In addition, imidazole, isoxazole, oxazole, pyrimidine, purine, and others are components of both natural compounds and medicines, while 1,3,5-triazine is also a component of pesticides. Research object: new derivatives of nitrogen-, sulfur-, and oxygen-containing heterocyclic compounds. The purpose of the research: synthesis of new derivatives of condensed and non-condensed nitrogen-, sulfur- and oxygen-containing heterocycles and research of their pharmacological action on living systems. Research methods: organic synthesis, physicochemical methods of analysis of synthesized substances (NMR spectroscopy on 1H and 13C nuclei, chromatography-mass spectroscopy, thin-layer chromatography), pharmacological screening, comparative and statistical data processing methods. Scientific novelty of the results: a number of new derivatives of nitrogen-, sulfur-, and oxygen-containing heterocycles have been synthesized, including compounds with arylisooxazole, di- or triazacyclopentaazulene, imidazopyridine, imidazotriazenine, 1,3-oxazole, 1,2,4- or 1,3,5- triazine, pyrazolothiazolidine, triazolotriazine, pyrimidinetrione and triazoloazepine cycles. It was established that the obtained heterocycles can serve as bioactive substances (BAS) and as active substances of medicinal substances. Product Description popup.authors Demchenko Anatolii M. Moskalenko Oleh V. Potebnia Hryhoii P. Simonian Liusine S. Fedchenkova Yuliia A. Tsyhankov Serhii A. popup.nrat_date 2025-01-11 Close