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Information × Registration Number 0225U000420, (0124U000552) , R & D reports Title Determination of optimal parameters of new nanofibrous biomaterials with hemostatic properties for emergency and military medicine popup.stage_title Розробка багатошарових мембран із полімерних розчинів (хітозан, PCL/PVA) Head Korniienko Viktoriya V., Кандидат медичних наук Registration Date 11-01-2025 Organization Sumy State University popup.description1 The goal of the project is to determine the possibility of using new three-layer nanofibrous membranes (produced by electrospinning) to provide hemostasis and antibacterial functions in the lower layer (chitosan-AgNPs), retain moisture and absorb exudate in the middle layer (chitosan-PVA), and promote tissue formation in the upper layer (PCL/PVA-FGF2-STAB) popup.description2  As part of the research phase, new scientific results were obtained regarding fabricating membranes based on chitosan and polylactic acid (Ch/PLA) using electrospinning. The membrane fabrication process was optimized by adjusting key electrospinning parameters, such as the polymer solution feeding rate (1.5 ml/hour) and voltage (25 kV), which allowed the production of stable membranes with specified physicochemical properties at a temperature of 21-23 °C and humidity below 35%. To stabilize the membrane structure, they were treated with a 1M NaOH solution. It was found that the polymer ratio in the mixture significantly influences the electrospinning process and the structural and mechanical properties of the resulting membranes. Solutions containing 8% chitosan and 8% polyethylene oxide (PEO) became electrospinnable after adding polylactic acid in the range of 1% to 4%. Special attention was given to adding polylactic acid, which significantly improved the electrospinnability of the solutions. Increasing the polylactic acid concentration contributed to the formation of thinner and more uniformly distributed fibers, enhancing the mechanical properties of the membranes. Adding polyethylene glycol (PEG) as a co-solvent enabled the formation of fibers without thickening and increased the number of thinner fibers with diameters less than 100 nm. The membranes obtained with PEG had a porous structure with pores smaller than 50 nm², which is important for biomedical applications. The practical significance of the obtained results lies in the ability to adjust the electrospinning parameters for different applications individually. The resulting membranes with a uniform porous structure and reduced fiber diameters open new possibilities for use in biomedical technologies, particularly for the creation of wound dressings, biocompatible barriers, and drug delivery systems Product Description popup.authors Varava Yuliia V. Husak Yevheniia V. Kyrylenko Serhii D. Korniienko Viktoriia V. Samokhin Yevhen O. Yalyzhko Milena V. popup.nrat_date 2025-01-11 Close