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Information × Registration Number 0225U000603, (0122U001202) , R & D reports Title To investigate the role of cytokine regulation taking into account the polymorphism of cytokine genes (TNF-α, TGF-β1, IL-6, IL-10, IFN-γ) in the pathogenesis of plasma cell myeloma in persons suffered by the Chornobyl accident popup.stage_title Комплексна характеристика стану цитокінової регуляції і регенеративного потенціалу кісткового мозку в залежності від цитокінового генотипу та оцінка внеску імуногенетичної компоненти в перебіг плазмоклітинної мієломи у хворих, які постраждали внаслідок аварії на Чорнобильській АЕС Head Minchenko Zhanna M., д.б.н. Registration Date 14-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 Based on the study of polymorphism of promoter regions of cytokine genes (TNF-α, TGF-β1, IL-6, IL-10, IFN-γ) and the state of cytokine regulation at different stages of therapy in patients with plasma cell myeloma in the remote term after the Chornobyl accident to define the role of the studied factors in the pathogenesis of the disease to predict the course of the pathological process and assess the effectiveness of treatment popup.description2  The object of the study is clinical hematological, immunogenetic, molecular-genetic characteristics of plasma cell myeloma (PCM). The objective of the study is to determine the role of the investigated factors in the pathogenesis of the disease to predict the course of the pathological process and assess the effectiveness of treatment based on the study of the cytokine gene promoter polymorphisms (TNF-α, TGF-β1, IL-6, IL-10, IFN-γ) and cytokine regulation dynamics at various stages of therapy in patients with plasma cell myeloma in the long-term period following the Chornobyl Nuclear Power Plant accident to determine the role of the investigated factors in the pathogenesis of the disease to predict the course of the pathological process and assess the effectiveness of treatment. Research methods: clinical, molecular-genetic, immunogenetic, and statistical. A study was conducted to evaluate the distribution of polymorphic variants of cytokine genes and the cytokine balance, taking into account the disease stage and radiation exposure history. A total of 124 patients were examined, including 53 with documented prior exposure to radiation. A probable correlation was found between changes in IL-6, TNF-α, and IL-10 production, post-cytostatic bone marrow recovery potential, and the clinical course of PCM. These findings suggest a substantial involvement of the cytokine network in PCM pathogenesis and highlight the potential for using serum levels of pro- and anti-inflammatory cytokines as criteria for assessing the clinical course of the disease.In irradiated patients, the immune response to the development of a pathological process exhibited features of a "cytokine storm" characterized by excessive IL-6 production, which is a sign of a shift in the nature of the body's immune response to the position of the pathological platform, which confirms the significance of the radiation component as a possible predictor of a severe clinical course of the disease. Product Description popup.authors Balan Valentyna V. Dmytrenko Olena O. Silaiev Yurii O. popup.nrat_date 2025-01-14 Close