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Information × Registration Number 0225U000665, (0124U001480) , R & D reports Title Research on the role of the genetic polymorphism of manganese superoxide dismutase, markers of oxidative and psychological stress and their interrelationships in the pathogenesis of the development of broncho-obstructive syndrome in children - residents of radioactively contaminated areas and children who were affected by stressful life events during the wartime period popup.stage_title Визначення розподілу генотипів поліморфізму Val16Ala -SOD2, маркерів оксидативного та психологічного стресу, показників вентиляційної спроможності легенів у дітей – мешканців РЗТ, дітей, які зазнали впливу стресових життєвих подій у період воєнного часу. Head Kolpakov Ihor Ye., Доктор медичних наук Registration Date 15-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 to determine the role of the Val16Ala-SOD2 polymorphism of the superoxide dismutase gene, markers of oxidative and psychological stress in the pathogenetic mechanisms of the development of respiratory system disorders and to establish their significance for predicting the risk of developing broncho-obstructive syndrome in children living in radioactively contaminated areas and children who were affected by stressful life events during the war time popup.description2 In children in both main groups, a tendency was found to increase in the serum content of lipid peroxidation end products in children with bronchial hyperreactivity, a tendency to decrease the activity of superoxide dismutase and to increase the activity of catalase and glutathione peroxidase. This is explained by the general tendency to greater stress of the antioxidant system in children with bronchial hyperreactivity. Assessment of the level of influence and personal perception of stressful life events showed that 23.81% of all children had high levels of psychological stress, while these levels were twice as high among children living in the RRT compared to children affected by the war. The study of the polymorphic marker Val16Ala-SOD2 of the SOD gene in children in both main groups did not reveal any significant differences between the frequency distribution of genotypes and alleles compared to the reference values ​​of the control group. In children of the observation groups, no significant differences in the frequency distribution of alleles C and T of the polymorphic marker Val16Ala-SOD2 of the SOD gene were found compared to other representatives of the Caucasian race. Among children - residents of the RRT, compared to children who were exposed to stressful life events during the war, there was a tendency to reduce the frequency of homozygotes with the SS genotype and to increase the frequency of heterozygotes with the ST genotype. Among children of both main groups, in ST heterozygotes of the Val16Ala-SOD2 polymorphism of the SOD gene, there was a tendency to increase the frequency of bronchial hyperreactivity compared to SS homozygotes. Among the adverse factors that increase the risk of bronchial hyperreactivity in children, the leading role is played by hereditary predisposition to bronchopulmonary pathology, which is characterized by the presence in the family, especially among first- and second-degree relatives of persons with asthma, COPD Product Description popup.authors Vdovenko Vitalii Yu. Zyhalo Viktor M. popup.nrat_date 2025-01-15 Close