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Information × Registration Number 0225U000668, (0123U101256) , R & D reports Title Assessment of anxiety in children during wartime and determination of the role of the 5-HTTLPR promoter polymorphism of the serotonin transporter gene SLC6A4 in its formation popup.stage_title Продовження проведення психологічного та молекулярно-генетичного обстеження дітей, які зазнали дії стресових життєвих подій в період воєнного часу. Head Kolpakov Ihor Ye., Доктор медичних наукChumak Anatolii A., Доктор медичних наук Registration Date 15-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 To determine the relationships between stressful life events, 5-HTTLPR promoter polymorphism of the SLC6A4 serotonin transporter gene, and psychological characteristics of children to predict the likelihood of developing anxiety states during wartime. popup.description2  It was found that the vast majority of surveyed children (76.19%) had an increased level of perceived stress, its strongest trigger was the factor “Direct witnessing hostilities”, and the stress reinforcing factor was “Regular access to Internet resources that track military events” and “Airborne warning signal”. The majority of surveyed families (69.05%) noted a decrease in their material level, while 23.81% noted an increase in income. Compared to the previous year, the share of families with stable income decreased from 23.81 to 7.14%, which may indicate the processes of social stratification. According to the STAI scale, high personal anxiety was determined in 39.68% of children. High and moderate values ​​of reactive anxiety were observed in 82.54% of children, which caused a persistent tendency to perceive many life situations as threatening, reacting to them with anxiety, neurotic conflict and emotional breakdowns. The negative impact of stressful life events significantly accelerates the transformation of functional disorders into chronic somatic and psychosomatic pathology. The absolute majority of children (93.65%) were diagnosed with chronic diseases, and the pathological damage index was 7.05. Molecular genetic studies of polymorphic variants of the SLC6A4 gene revealed that the LL genotype (47.63%) is the predominant variant. Product Description popup.authors Abramenko Iryna V. Vdovenko Vitalii Yu. Zyhalo Viktor M. Leonovych Olena S. Poznysh Viktoriia A. popup.nrat_date 2025-01-15 Close