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Information × Registration Number 0225U000747, (0120U100150) , R & D reports Title Stable carbenes of heterocyclic and acyclic series. Synthesis and physico-chemical properties popup.stage_title Дослідження структури та фізико-хімічних властивостей нових типів стабільних карбенів Head Korotkikh Mykola I., Доктор хімічних наук Registration Date 18-01-2025 Organization Institute of Physical and Organic Chemistry and Coal Chemistry. LM Litvinenko of the National Academy of Sciences of Ukraine popup.description1 The purpose of the research is the synthesis of stable carbenes of heterocyclic and acyclic series (highly basic and highly electron donating - mesoionic, ylidic, superbasic, sterically developed, new types of structures), studying their properties, obtaining derivatives and studying their structure and physical propertie popup.description2  Object of research. New stable carbenes of the 1,2,4-triazole series containing halogen atoms (fluorine, chlorine) in the structure were synthesized, the first representative of carbenes of the pyridine series, new complexes of stable carbenes of the ylide type of the imidazole and benzimidazole series. The obtained compounds are intended for the creation of efficient catalysts of organic reactions and new biologically active compounds. The aim of the work is to study the synthesis of new types of stable carbenes with frontier properties, the development of methods for the synthesis of carbene complexes of a new type. Research methods are synthetic, spectral (NMR spectroscopy), analytical (chromatographic, elemental analysis), computational (quantum chemical studies). Research results. New methods for the synthesis of stable carbenes of the 1,2,4-triazole series containing halogen atoms (fluorine, chlorine) in the structure were developed. Among them, compounds with the lowest basicity compared to known stable carbenes were found. Based on 2,6-diisopropylaniline and cyclohexane carbaldehyde, sterically protected piperidin-2-ylidene was synthesized - the first representative of the pyridine series of stable carbenes. Copper(I) carbene complexes based on N-ylide carbenes were synthesized for the first time. Methods for the synthesis of a number of carbene and biscarbene complexes of silver were developed, and their structure was established by X-ray diffractometry. High antibacterial and antifungal activity of a number of carbene complexes of silver was revealed. Field of application - synthesis of stable carbenes and their carbenoid forms, medicinal chemistry. Product Description popup.authors Yenia Vasyl I. Hordieieva Iryna O. Hresko Serhii V. Dziuba Oksana I. Knishevytskyi Artur V. Konovkina Olha A. Nechytailov Maksym M. Raienko Hennadii F. Redko Anastasiia V. Skorobohatova Zoia M. Ustilko Yuliia O. Shvaika Roksolana O. Shendrik Tetiana H. popup.nrat_date 2025-01-18 Close