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Information × Registration Number 0225U000815, (0121U112068) , R & D reports Title Laboratory-experimental and preclinical substantiation of the use of new complex solutions for "low-volume" infusion therapy popup.stage_title Завершити вивчення специфічних фармакологічних властивостей розчинів в експерименті. Дослідити стабільність розроблених розчинів в процесі тривалого зберігання. Розробити інструкції для клінічного вивчення розчинів Head Kondratskiy Bogdan O., Доктор медичних наукNovak Vasyl L., Доктор медичних наук Registration Date 19-01-2025 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description1 To prove in animal experiments applicability of two new multicomponent infusion solutions; confirm the manufacturability of their production and stability during prolonged storage popup.description2 The morphological changes in the organs of experimental animals following the administration of a protein-salt hyperosmolar preparation based on donor albumin (AXAM) and a combined crystalloid hyperosmolar solution (XLM) are presented. It was experimentally established that the administration of the AXAM solution and the XLM solution at a dose of 10 ml/kg daily for 30 days does not negatively affect the blood coagulation system of experimental animals, including screening coagulation tests and thromboelastogram parameters. In a rabbit model of toxic hepatitis, it was shown that administering AXAM and XLM at a dose of 10 ml/kg daily for 14 days reduced the impact of the toxic agent. It was determined that these solutions are safe, do not have a negative effect on the damaged liver, and that infusion therapy with these solutions in experimental toxic hepatitis reduces the severity of the disease. The results of a clinical study of the previously developed infusion preparation Sorbilact in oncology patients with stomach cancer after gastrectomy with splenectomy (50 patients), rectal cancer after anterior resection of the rectum (60 patients), and sigmoid colon cancer after sigmoid colon resection (45 patients) during the early postoperative period are presented. Product Description popup.authors Ivasyk Viktor V. Bereketa Yaroslav D. Brahinets Olena H. Vynarchyk Mariia Y. Dzis Roman P. Kachmaryk Diana L. Kondratskyi Bohdan O. Kondratskyi Yaroslav B. Krasivska Valeriia V. Morhun Yuliia O. Novak Vasyl L. Orlyk Volodymyr V. Panas Oksana M. Prymak Sofiia V. Rohatynska Yaroslava V. Tarasiuk Oleksandra O. popup.nrat_date 2025-01-19 Close