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Information × Registration Number 0225U000835, (0122U001430) , R & D reports Title Study of regularities of development of endocrine disorders and concomitant diseases associated with normocalcemic disorders of parathyroid glands in persons affected by the Chornobyl NPP accident popup.stage_title Виявлення супутніх захворювань, які можуть бути асоційованими з патологією прищитоподібних залоз у осіб, які постраждали внаслідок аварії на ЧАЕС у віддаленому періоді опромінення Head Kaminskyi Oleksii V., Доктор медичних наук Registration Date 20-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 To study the normocalcemic disorders of parathyroid glands (hyperplasia, adenoma, secondary hyperparathyroidism) and identify the endocrine disorders and comorbidities in persons affected by the Chornobyl NPP accident and their descendants in the late period upon exposure; develop the clinical guidelines for diagnosis, prevention and treatment of parathyroid gland disorders popup.description2  Pathophysiological patterns of the development of hormonal and metabolic disorders and concomitant diseases associated with normocalcemic pathology of parathyroid glands in persons affected by the Chornobyl accident, their descendants and servicemen of the Defense Forces of Ukraine have been revealed, consisting in the sequence (stages) of development and clinical course of structural and functional changes from its hyperplasia to tumoral (benign) transformation, hyperparathyroidism and hypercalcemia. There was a high prevalence of parathyroid hyperplasia in irradiated persons (24.6%), being 1.5 times more common than in persons of the control group (18.03%). Retrospectively, their frequency was 26.3% for the municipal workers, evacuated from the 30-km exclusion zone, residents of radioactively contaminated territories. In a retrospective study, the incidence of normocalcemic nonrenal hyperparathyroidism was 20.5% in individuals affected by the Chornobyl accident being slightly higher than in controls (16.4%). However, there was a gradual increase in the incidence of hyperparathyroidism over time in all study groups (approximately 1% per year). It was found that parathyroid hyperplasia was more common in children born to irradiated individuals (42.8%) than in controls (37.1%). Compared with adults the incidence of this disorder in children was more than twice as high (24.6% vs. 18.03%, respectively). There were developed clinical approaches and methodological recommendations for the management of non-renal secondary hyperparathyroidism and individualized dosage of vitamin D addressing the issues of staging of structural and functional pathophysiological changes in parathyroids, timely clinical and ultrasound diagnostics, and allowing the application of therapeutic and preventive measures in persons affected by the Chornobyl accident, their descendants, and servicemen of the Defense Forces of Ukraine. Product Description popup.authors Afanasiev Dmytro Ye. Kaminskyi Oleksii V. Kopylova Olha V. Muraviova Olena M. Chykalova Iryna H. popup.nrat_date 2025-01-20 Close