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Information × Registration Number 0225U000901, (0120U101780) , R & D reports Title The effects of biologically active substances of natural origin for the correction of pathologies accompanied by hyperglycemia popup.stage_title Дослідження дії біологічно активних речовин природного походження з метою корекції патологій, що супроводжуються гіперглікемією Head Sybirna Nataliia O., Доктор біологічних наук Registration Date 21-01-2025 Organization Ivan Franko National University of Lviv popup.description1 Investigate the antioxidant activity of extracts of Galega officinalis, yacon (Smallanthus sonchifolius Poepp. & Endl.), concentrate of red grape wine and medicinal mushrooms (Agaricus brasiliensis, Ganoderma lucidum (Higher Basidiomycetes), depending on the content of phenolic nature biologically active substances. Phenolic compounds are able to trap free radicals, with the prospect of using these extracts as the basis of medicines for the prevention and treatment of pathologies caused by oxidative stress popup.description2  The object of study is blood glucose level, oxidative-nitrative stress and functional state of blood cells and pancreas under diabetes mellitus and metabolic syndrome. The aim of the study is to investigate the hypoglycemic and antioxidant effects and corrective effect on blood cells of extracts of Galega officinalis L., Cornus mas L. and red grape wine polyphenol complex concentrate, and Ganoderma lucidum is a well-known medicinal mushroom under metabolic disease that is characterized by hyperglycemia (diabetes mellitus and metabolic syndrome). Research methods: biochemical, immunocytochemical, cytological, statistical. Results. The hypoglycemic and antioxidant effects of the alkaloid-free fraction of extracts of G. officinalis and C. mas, concentrate of the polyphenolic complex of red grape wine and medicinal mushroom G. lucidum under the conditions experimental diabetes mellitus and metabolic syndrome; modifying effect of natural grape wine polyphenolic complex on the state of the L-arginine/NO system; hypoglycemic and hepatoprotective effects of loganic acid under experimental diabetes mellitus and the corrective effect of G. lucidum mycelium suspension on haematological parameters and plasma lipid profile in metabolic syndrome. The obtained results confirm the corrective effect of biologically active substances isolated from G. officinalis, cornelian cherry fruits (C. mas ), medicinal mushroom G. lucidum and polyphenolic concentrate of red grape wine on glycation processes and their hypoglycemic and hypolipidemic effects under disease characterized by hyperglycemia. Product Description popup.authors Brodiak Iryna V. Hachkova Halyna Ya. Moroz Anna M. Nahalievska Mariia R. Petryn Tetiana S. Sabadashka Mariia V. Sybirna Nataliia O. Chala Dariia Yu. popup.nrat_date 2025-01-21 Close