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Information × Registration Number 0225U000903, (0123U100691) , R & D reports Title To study the role of epigenetic mechanisms in the progression of immunometabolic disorders in the combination ischemic heart disease and type 2 diabetes mellitus in conditions of stress caused by military actions and their consequences popup.stage_title Вивчити роль епігенетичних механізмів у прогресуванні імунометаболічних порушень при поєднанні ішемічної хвороби серця з цукровим діабетом 2 типу в умовах стресу, викликаного воєнними діями та їх наслідками Head Serik Serhii A., Доктор медичних наук Registration Date 21-01-2025 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description1 To investigate the pathogenetic and therapeutic significance of circulating long non-coding ribonucleic acids ANRIL and MALAT1 in the progression of metabolic disorders and inflammatory activation in patients with coronary heart disease with type 2 diabetes mellitus under the influence of carried traumatic stress events in the hostilities zone. popup.description2 During the examination of civilians who had been permanently living in Kharkiv and in the unoccupied part of the Kharkiv region since the beginning of the war, it was established that patients with coronary artery disease (CAD) with type 2 diabetes (T2DM) have more pronounced psycho-emotional disorders (manifestations of probable post-traumatic stress disorder (PTSD), general anxiety, level of perceived stress) than in patients with CAD without T2DM and the control group. Compared to civilians, military personnel have a higher level of general anxiety, a sense of stress, and a higher proportion of people with signs of probable PTSD. When studying long non-coding RNAs (ncRNA) in civilian CAD patients with and without T2DM compared to the control group, elevated levels of linear ANRIL and MALAT1 were found. The combination of CHD with T2DM led to a further increase in the levels of atherogenic linear ANRIL and an independent decrease in atheroprotective circular ANRIL with a decrease in their ratio. In the combination of CHD with T2DM, patients with signs of probable PTSD and moderate to high levels of stress had higher values of linear ANRIL. In patients with CAD and T2DM, increased levels of MALAT1 and linear ANRIL correlated with hyperglycemia and decreased high-density lipoprotein cholesterol, decreased circulating ANRIL was associated with obesity and increased glycemia, and increased linear ANRIL was directly related to increased proinflammatory cytokine activity TNF-α. In patients with CAD and T2DM, the atheroprotective effect of statins and empagliflozin is mediated by a beneficial effect on the expression of ncRNAs involved in the pathogenesis of diabetic atherosclerosis. In patients with CAD and T2DM, the effect of statins on inflammatory activity and signs of diabetic dyslipidemia is determined by baseline levels of MALAT1 and linear ANRIL, confirming the importance of ncRNA as predictors of anti-inflammatory and lipid effects of statins Product Description popup.authors Antonova Inna V. Bondar Tetiana M. Buhrimenko Halyna P. Voronova Nadiia I. Horb Yurii H. Kolesnikova Olena M. Kostiuk Olena I. Malko Viktoriia V. Moroz Olha S. Riabukha Vladyslav V. Serik Serhii A. Strona Volodymyr I. Tkachenko Olha V. Tokareva Alona Yu. Trybushkina Iryna M. Tsedryk Liudmyla A. Chenchyk Tetiana O. popup.nrat_date 2025-01-21 Close