Updated: 2025-12-08
Total number
Full text
Total number
Full text
Number of local repositories
Full text
0225U000926, (0121U112326) , R & D reports
Developing the algorythm for minimal residual disease diagnostics and immunological rehabilitation in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma after antineoplastic program therapy
Розробити алгоритм діагностики МЗХ, який дозволить індивідуалізувати лікувальну тактику у хворих на ХЛЛ/ЛМЛ, а також запропонувати комплекс заходів імунологічної реабілітації та профілактики ускладнень у хворих на ХЛЛ/ЛМЛ, зокрема у пацієнтів з коронавірусною хворобою.
Vyhovska Yaroslava I., д.мед.н.
Masliak Zvenyslava V., д.мед.н.
21-01-2025
State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine"
Developing the algorythm for minimal residual disease (mrd) diagnostics and immunological rehabilitation in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll) after antineoplastic program therapy based on the immunophenotypic features of the leukemic and normal peripheral blood lymphocytes as well as parameters of the immune status in these patients.
A group of 87 patients treated for chronic lymphocytic leukemia (CLL) were investigated. In 57 (65,5%) of these patients with confirmed complete response minimal residual disease was analyzed and treatment efficacy was evaluated according to its depth. It was found that minimal residual disease (MRD) negative cohort did not have CLL progression, their median progression-free survival was not reached within duration of the study and the only registered death event was related to infection which developed after completion of CLL treatment. Among 14 patients of this MRD-negative group 7 individuals (50%) received modern targeted medications within their last treatment line. We found that all 3 detected CLL progression cases occurred in the cohort of MRD-positive patients. Of note only 1 of these 26 patients received targeted treatment of leukemia. Overall survival rates were confirmed to be higher in MRD-negative group. Part of the CLL patients were found to have decreased levels of IgG below 4,60 g/L which required substitution therapy. Application of the i.v. immunoglobulin G medications enabled bringing its levels to normal within 3 to 6 months. Multicolor flow cytometry panel including 10 types of monoclonal antibodies was developed for detection and evaluation of MRD status in CLL. In complicated cased the panel was recommended to be extended to 15 markers. The MRD diagnostics algorithm was suggested for individualization of the treatment strategy, immunological rehabilitation and prophylaxis of complications in CLL patients which would enable timely detection of disease relapse, have positive impact on the quality of life of the patients and decrease number of immunosuppression-related complications.
Horodyska Tetiana O.
Danysh Olha Yo.
Knysh Nataliia V.
Lukavetskyi Les M.
Miliashkevych Halyna B.
Melnyk Mariia I.
Prymak Sofiia V.
Thir Hrystyna R.
Tsyapka Orest M.
Yurchyshak Iryna M.
2025-01-21
Updated: 2025-12-08
Saving a scientific data set occurs in two stages:
1.) Creating a data set
Enter the name of the set, a brief description of the set (annotation), and click the “Create set” button. After that, a draft data set will be automatically created, which you can save for further work with the set. The system will redirect you to the “Data set information” page.
2.) Filling in the data
On the “Data set information” page, you need to fill in all the fields related to the data set and upload the files.
Please note! Each file is uploaded separately. This is done to ensure the stable operation of the system.
Once you have filled in the information about the scientific data set and added the necessary files, you can save the draft or send the data to the system.
Please note! Once the data has been sent, you cannot change it.
Drafts are necessary for storing the data set and editing it before sending.
All accounts on the NRA website go through a standard registration procedure and are verified. However, in order to obtain additional features, such as publishing open reviews of academic texts, verification by affiliation is required.
To obtain the status “verified”, you must change your primary email address to a corporate one, which is tied to a scientific or educational institution.
For example: user@ukrintei.ua, user@nas.gov.ua
After confirming your corporate email address, your account will be automatically verified by affiliation.
If your email address is corporate, but your account does not have a verification mark, you need to write to us at the email address NRAT@ukrintei.ua. After verification, we will add your address to the database, and your account will be verified.
After completing the verification procedure for affiliation, you can change the primary email address to a convenient one for you, without losing your status during the current verification.
You only need to verify for affiliation once.
* We use corporate addresses from the Unified State Database on Education and the State Register of Scientific Institutions Supported by the State
To search for news published on the official website of NRАT in the “News” section, you need to enter one word, several words, or an exact phrase in the search field. Different terms are separated by spaces.
The search is performed everywhere – in the title and the news text.
For a more comprehensive result, it is recommended to use word stems (parts of words without endings).
When using multiple words for the search, they are combined using one of the logical methods described below.
By default, the logical connector “and” is used. In this case, search results will include all news releases that contain the specified words, even if they are located separately from each other and are in different parts of the text.
Example: Search phrase: OECD report. Search result: all news containing the words “report” and “OECD” in the text and in the title, both together and separately.
If a phrase or phrase is enclosed in quotation marks (“), the results will include all publications where this exact phrase or phrase is found.
Example: Search phrase: “OECD report.” Search result: all news containing the exact phrase “OECD report.”
If you know the publication date of the news or are interested in a specific time frame in which they were published on the website, you can select such a date or date range in the additional field that looks like a calendar. The date is entered in the format year-month-day and confirmed by clicking on the corresponding date in the calendar dropdown. You can enter a date or choose one by browsing through the calendar by months and years. By default, the interval starts from the oldest date (2018-01-23) and ends with the current date.
You can also use one or more hashtags, which are located under the search field on the right side of the “News” page.
Please note: The search for academic texts is carried out in a separate search window at the following link https://nrat.ukrintei.ua/searchdb.