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Information × Registration Number 0225U000938, (0121U000201) , R & D reports Title To study the course of COVID-19 infection in patients with different immunological status, to develop methods for the diagnosis and treatment of neurological complications popup.stage_title Дослідити перебіг інфекції COVID-19 у пацієнтів з різним імунологічним статусом, розробити методи діагностика та лікування неврологічних ускладнень Head Панасюк Олена Леонідівна, Шагінян Валерія Робертівна, Дьяченко Павло Анатолійович, Registration Date 21-01-2025 Organization State Institution "LV Gromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine" popup.description1 popup.description2  AL RESEARCH REPORT: 188 PAGES, 33 TABLES, 35 FIGURES, 133 SOURCES. THE OBJECT OF THE STUDY IS COVID-19 PATIENTS, NEUROINFECTIONS, PLHIV. THE PURPOSE OF THE WORK IS TO DETERMINE THE FEATURES OF THE CLINICAL, IMMUNE STATUS, THERAPY (INCLUDING INTENSIVE CARE) OF PATIENTS WITH COVID-19 AND WITH NERVOUS SYSTEM LESIONS. SCIENTIFIC NOVELTY OF THE WORK. FOR THE FIRST TIME IN UKRAINE, IT HAS BEEN SHOWN THAT THE DEVELOPMENT OF THE COVID-19 EPIDEMIC PROCESS FOLLOWS THE PATH OF OTHER RESPIRATORY INFECTIONS, THERE IS A DECREASE IN THE VIRULENCE OF THE PATHOGEN AND AN INCREASE IN ITS CONTAGIOUSNESS. FOR THE FIRST TIME IN UKRAINE, IT HAS BEEN SHOWN THAT IN PATIENTS WITH POST-COVID SYNDROME, CLINICAL MANIFESTATIONS OF DAMAGE TO THE CENTRAL AND PERIPHERAL NERVOUS SYSTEM OCCUR MUCH MORE OFTEN AND LAST LONGER THAN IN PATIENTS WITHOUT A HISTORY OF COVID. EXCLUSIVELY FOR UKRAINE, IT HAS BEEN FOUND THAT IN PATIENTS WITH LONGCOVID, PRONOUNCED DISORDERS OF THE CELLULAR IMMUNE RESPONSE OCCUR, AND THE FUNCTIONAL ACTIVITY OF EFFECTOR CELLS OF THE IMMUNE SYSTEM DECREASES. WHEN ANALYZING THE CLINICAL AND LABORATORY CHARACTERISTICS OF PATIENTS WITH INFECTIOUS AND INFLAMMATORY DISEASES, IT WAS FOUND THAT THE FAVORABLE FACTORS FOR THE DEVELOPMENT OF THIS PATHOLOGY WERE THE DEVELOPMENT OF ENDOCRINOPATHY, DRUG-INDUCED SECONDARY IMMUNODEFICIENCY AND PROLONGED USE OF HORMONAL AND ANTIBACTERIAL DRUGS. THE MOST COMMON WAS NEWLY DIAGNOSED TYPE 1 DIABETES MELLITUS (51.43%). IT WAS FOUND THAT A FAVORABLE FACTOR IN THE DEVELOPMENT OF ADRENAL INSUFFICIENCY IN ALL PATIENTS WAS PROLONGED HIGH-DOSE STEROID THERAPY. PRACTICAL SIGNIFICANCE OF THE WORK. BASED ON THE RESULTS OF THE EXAMINATION AND QUESTIONNAIRE, IT WAS PROVEN THAT VACCINATION AGAINST COVID-19 LEADS TO AN IMMUNE RESPONSE WITH THE PRODUCTION OF A PROTECTIVE LEVEL OF ANTIBODIES, BUT DOES NOT ALWAYS PREVENT THE DEVELOPMENT OF THE DISEASE. FOR THE FIRST TIME IN UKRAINE, IT HAS BEEN SHOWN THAT PATIENTS AFTER COVID-19 HAD A LOWER QUALITY OF LIFE THAN PEO Product Description popup.authors Antoniak Svitlana M. Borshchov Serhii P. Klius Viktoriia Yu. Filchakov Ihor V. Shahinian Valeriia R. popup.nrat_date 2025-01-21 Close