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Information × Registration Number 0225U000942, (0122U000544) , R & D reports Title Comparative study of the proliferative activity of BRAFV600E positive and BRAFV600E negative radiogenic and sporadic papillary thyroid carcinomas in patients of different ages due to the invasive properties of tumors and the postoperative course of disease popup.stage_title Порівняльне дослідження проліферативної активності BRAFV600E позитивних і BRAFV600E негативних радіогенних і спорадичних папілярних тиреоїдних карцином у хворих різного віку з огляду на інвазійні властивості пухлин та післяопераційний перебіг захворювання Head Bohdanova Tetiana I., д.б.н.Tronko Mykola D., Доктор медичних наук Registration Date 22-01-2025 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description1 To continue monitoring the incidence of thyroid cancer in children and adolescents of Ukraine affected by the Chornobyl accident; to determine the possibility of an association between proliferative activity, invasive properties of tumors, the presence of BRAFV600E mutation and the development of disease recurrence in radiogenic and sporadic papillary thyroid carcinoma in patients of different ages popup.description2  Object of the study - thyroid cancer (TC) incidence, histopathological characteristics of papillary thyroid carcinoma (PTC), BRAFV600E mutation in PTC. Ki67 Labeling Index (Ki67 LI) The aim of the study is to continue monitoring the incidence of thyroid cancer in children and adolescents of Ukraine affected by the Chornobyl accident, to determine the possible associations between proliferative activity, tumors invasive properties, the presence of BRAFV600E mutation and the development of disease recurrence in radiogenic and sporadic PTCs in patients of different ages. Methods of the study - morphological, immunohistochemical, statistical. Results: Increased Ki67 LI in radiogenic and sporadic PTCs of young patients aged up to 29 years is unidirectionally associated with smaller tumor size, dominant papillary growth pattern, oncocytic changes, and more frequent BRAFV600E mutation. Similar associations also extended to radiogenic PTCs of patients aged up to 49 years at operation. In radiogenic PTCs, unlike sporadic ones, an increase in Ki67 LI is associated with a worse postoperative prognosis, namely with an increase in the probability of developing recurrent metastases, including radioiodine-refractory ones, which is associated, in turn, exclusively with the BRAFV600E negative status of PTC. BRAFV600E positive PTC, regardless of their etiology and age of patients at the time of surgery, are associated with a higher Ki67 LI compared to BRAFV600E negative tumors, but its further increase does not affect the clinical and histopathological indicators of PTC and the prognosis of the disease. Implementation effectiveness: Improvement of diagnostics, treatment tactics and postoperative prognosis of radiogenic PTC considering the impact of increased Ki67 LI on BRAFV600E negative tumors. Implementation level: papers, presentations, Field of use: endocrinology, pathology, oncology, radiation medicine. Product Description popup.authors Bolhov Mykhailo Yu. Burko Svitlana V. Hulievatyi Serhii V. Hulak Liudmyla O. Dehtiarova Tetiana L. Zurnadzhy Liudmyla Yu. Krysaiev Ihor H. Lubskyi V'iacheslav O. Mazuryk Nataliia Ya. Chernyshov Serhii V. Shpak Viktor M. popup.nrat_date 2025-01-22 Close