Search academic texts

Information × Registration Number 0225U001031, (0123U101248) , R & D reports Title Development and implementation of innovative technologies for the diagnosis of oncogynecological and oncourological diseases based on liquid biopsy data of extracellular DNA and stem cells popup.stage_title Виявлення та оцінка нових молекулярно-генетичних факторів, як потенційних маркерів диференціальної діагностики і прогнозу урологічного раку. Head Komarevtsev Vitalii M., д.мед.н. Registration Date 23-01-2025 Organization The State Institution "Lugansk State Medical University" popup.description1 Development of new methods of biomarker diagnostics of oncogynecological and oncourological diseases based on liquid biopsy data of extracellular DNA, markers of epithelial-mesenchymal transformation and stem cancer cells. popup.description2  The identification and evaluation of new molecular genetic factors that could become, on the one hand, markers for differential diagnosis and prognosis of prostate cancer (PCA), and on the other hand, become a target for targeted therapy. Our study of the content of nitric oxide in prostate adenocarcinoma tissue showed that its concentration is increased in all groups of patients with different stages of prostate cancer compared to the control group. The bifunctional nature of nitric oxide in the genesis of prostate cancer was established. Based on the studied indicators, a classification of the adenocarcinoma phenotype was developed, which allows predicting the risk of tumor metastasis. Molecular genetic groups of highly aggressive forms of prostate cancer were identified. The role of the biomarker of nitric oxide metabolites in the progression and metastasis of renal cell carcinoma to the brain was studied. The apoptosis activity of the gastric mucosa and kidneys was determined by the level of fragmented DNA under conditions of experimental restraint stress. Experimental immobilization stress has a significant effect on the level of DNA fragmentation in the renal medulla. The effects of stress are amplified during the first two weeks, after which the processes of adaptation or recovery begin. Product Description popup.authors Balabanova Kateryna V. Karasov Ihor E. Komarevtsev Vitalii M. Moraru-Burlesku Roman P. Serohina Nataliia M. Frolova Inna V. Chernykh Yurii A. Shypilov Kostiantyn V. Yusef Rami Mukhammed S. popup.nrat_date 2025-01-23 Close