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Information × Registration Number 0225U001032, (0123U101247) , R & D reports Title Diagnostic algorithm for determining the morphofunctional state of the stomach and duodenum under the conditions of exposure to toxic agents in military personnel and in the experiment popup.stage_title Розробка експериментальної моделі дії епоксидів і їх сполук на клітини слизової оболонки шлунку і дванадцятипалої кишки. Head Smirnov Serhii M., Доктор біологічних наук Registration Date 23-01-2025 Organization The State Institution "Lugansk State Medical University" popup.description1 To establish the nature of damage to the gastrointestinal tract in military personnel, to develop experimental models of the action of chemical factors on the cells of the mucous membrane of the stomach and duodenum in order to establish the pathogenetic mechanisms of the toxic effect of exogenous epoxy agents and to find means of pathogenetic correction. popup.description2  Prolonged action of EPHG leads to a decrease in the height of CO DC villi and to a decrease in the mitotic activity of CO DC epithelial cells. A decrease in the height of villi is observed within 60 days after the end of EPHG administration. The severity of the decrease in the height of CO DC villi decreases in the period from 1 to 60 days after the end of EPHG administration. 2. Administration of EP extract to rats that did not receive EPHG is accompanied by an increase in the height of CO DC villi on day 1 of the study. From 1 to 60 days after the end of EPHG administration, the height of CO DC villi decreases. 3. Administration of thiotriazoline to rats that did not receive EPHG leads to an increase in the height of CO DC villi, which is observed within 15 days after the end of drug administration. During the period from 1 to 60 days of observation, the height of the villi of the CO DC of rats exposed to thiotriazoline decreases. 4. The use of the EP extract, as well as the use of thiotriazoline during inhalation of EPCHG reduces the severity and duration of the decrease in the height of the villi, as well as the duration of the decrease in the mitotic activity of the epithelial cells of the CO DC, caused by this chemical. Thiotriazoline is more effective than the EP extract in correcting the consequences of the negative effects of EPCHG. Product Description popup.authors Haidash Ihor S. Krektun Oleksandr V. Oliinyk Dmytro A. Smirnov Serhii M. popup.nrat_date 2025-01-23 Close