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Information × Registration Number 0225U001054, (0121U111542) , R & D reports Title Determination of hematologic disorders and disorders of hemostasis that developed as a result of COVID-19 popup.stage_title Дослідити взаємозв’язок між гематологічними порушеннями та наявністю і тяжкістю ускладнень у постковідному періоді та встановити особливості їх медикаментозної корекції Head Horiainova Nadiia V., д.мед.н. Registration Date 24-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 Improve the diagnosis and treatment of hematological disorders that occur after COVID-19 infection by establishing their structure, clinical and laboratory manifestations of postcocious syndrome. popup.description2  The object of the study is the features of hematological and hemostasis disorders in 333 patients who had COVID-19. The aim is to determine the severity, duration and features of the course of the most common hematological and hemostasis disorders that occurred in patients after COVID-19 infection. Research methods include clinical-hematological, biochemical, immunological, instrumental, and statistical approaches. New data have been obtained on the spectrum of hematological and hemostatic disorders following COVID-19. The most common hematological complications caused by coronavirus have been analyzed, particularly hemostatic system disorders (45%), such as hypercoagulable syndrome (HS) and thrombotic events (TE). It was found that cytopenias are predominantly immune in nature and include thrombocytopenia (26%), autoimmune hemolytic anemia (4%), Fisher-Evans syndrome (1%), and lymphopenia (4%). Hyperferritinemia was observed in 13% of patients. The indicators of the hemostasis system in patients after COVID-19 were studied, highlighting correlation between prothrombotic state and severity of acute COVID-19, and presence of post-COVID syndrome (PCS). Risk factors for venous thromboembolism (VTE) in these patients were identified. It was found that a higher risk of both HS and venous and arterial TE is observed in patients with PCS. Further, risk factors for VTE in outpatient patients with PCS include deviations in soluble fibrin-monomer complexes, fibrinogen, D-dimer, and APTT levels. Iron metabolism disorders, which in some cases are accompanied by anemia of chronic disease, reflect a long-term inflammatory process or appearance of other complications of COVID-19. The course of COVID-19 in patients with chronic lymphocytic leukemia was analyzed. It was determined that age over 75 years and the presence of comorbidities are statistically significant predictors of severe COVID-19 outcomes in this patient group. Medical and social effect. Medicine Product Description popup.authors Basova Olha V. Kyselova Olena A. Kuiavovych Bohdana M. Starodub Halyna S. Tretiak Nataliia M. Yahovdik Maryna V. popup.nrat_date 2025-01-24 Close