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Information × Registration Number 0225U001119, (0121U111536) , R & D reports Title To investigate the role of genetic and pharmacological modulators of energy homeostasis in the development of insulin resistance and associated vascular disorders popup.stage_title Дослідити роль генетичних і фармакологічних модуляторів енергетичного обміну в розвитку інсулінорезистентності та асоційованих судинних порушень Head Krasova Nataliia S., к.б.н. Registration Date 25-01-2025 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description1 Тo determine the contribution of energy homeostasis genetic modulators to the formation of insulin resistance in type 2 diabetes mellitus to further substantiate the prospects for the inclusion of sirtuin-1 activators in personalized therapy of chronic metabolic diseases and associated vascular complications popup.description2 The purpose of the work is to determine the contribution of genetic modulators of energy homeostasis to the formation of insulin resistance in type 2 diabetes for further justification of the prospects of including sirtuin-1 activators in the personalized therapy of chronic metabolic diseases and associated vascular complications. The synthesis of potential activators of sirtuin-1 - heterocyclic compounds with imidazole, pyrazole, thiazolone and indole fragments in the structure was carried out, their molecular structure and purity were established by physicochemical, spectral, chromatographic methods. The acute toxicity of the original derivatives of nitrogen-containing heterocycles was evaluated in vivo. In models of prediabetes and hyperlipidemic metabolic memory in rats, the effect of a promising sirtuin-1 activator compound, pyrabentin, under the conditions of long-term oral administration on the leading links in the development of obesity, type 2 diabetes and accompanying metabolic and physiological disorders was proven. On two models of experimental hepatitis, it was proven that a new combined agent based on a dicarboxylic acid derivative and a selenium-containing compound has pronounced antioxidant, detoxifying and membrane-stabilizing properties, the ability to positively influence metabolic processes in the liver, spermatogenesis та тиреоїдний гомеостаз і є перспективним як потенційний лікарський засіб для корекції функціонально-метаболічних порушень печінки та коморбідних ендокринних патологій. The functional role of SIRT1 (rs7069102, rs2273773) and TR53 (rs1042522) gene single-nucleotide polymorphisms in the Eastern Ukrainian population of type 2 diabetes patients was revealed. Field of application - health care, pharmaceutical industry.  Product Description popup.authors Bielkina Inna O. Borodina Viktoriia V. Bui Olha D. Vakula Volodymyr M. Hladkykh Oleksandr I. Kolesnikova Alla O. Kravchenko Svitlana V. Krasova Nataliia S. Kudria Mariia Ya. Lipson Viktoriia V. Leshсhenko Zhanna A. Misiura Kateryna V. Melnykivska Natalia V. Nikishyna Liudmyla Ye. Perets Olena V. Seliukova Nataliia Yu. Sydorova Iryna V. Tyzhnenko Tetiana V. Ustenko Nonna V. Yaremenko Fedir H. popup.nrat_date 2025-01-25 Close