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Information × Registration Number 0225U001132, (0123U100214) , R & D reports Title Complex systems for prevention and therapy of infectious diseases based on innovative forms of active chlorine popup.stage_title Дослідження антимікробних властивостей, субхронічної токсичності, окремих видів фармакологічної активності хлорактивних парів та аерозолів, та створення систем підтримки оптимальної концентрації активного хлору в повітрі приміщення Head Murashevych Bohdan V., к.х.н. Registration Date 26-01-2025 Organization Dnipro State Medical University popup.description1 Development scientific and technical principles for the creation of complex systems for disinfecting premises in the presence of people based on highly pure solutions of active chlorine, devices for introducing them into the air, and microbiocidal (including chlorine-active) polymer materials as air filters; creation of models and development of recommendations for the manufacture of personal protective equipment with antimicrobial and virucidal effects based on synthesized polymers; expantion of knowledges about the pharmacological properties of analogues of endogenous chlorine-active antimicrobial and anti-inflammatory agents (N-chlorotaurines and the like). popup.description2  The aim of this stage of the research was to create evaporation devices of a special design that take into account the specific properties of chlorine-active working solutions and can be used simultaneously for the synthesis of active chlorine and the administration of its volatile component - hypochlorous acid HOCl - into the air in a gaseous state. To achieve this, the influence of the properties of the working solution and the technological parameters of the prototype created at the previous stage on HOCl concentration in the air being treated was analyzed in detail. The influence of single and repeated inhalations of HOCl on the activity of enzymes of the antioxidant system of experimental animals was studied. A separate direction of the research was the synthesis and study of the chemical, antimicrobial and pharmacological properties of N-halotaurines, in particular N-chlorotaurine - one of the most important chlorine-active compounds of the immune system and a powerful endogenous microbiocide with the outstanding tolerability. At this stage, data on the use of highly pure N-chlorotaurine solutions for single and repeated infusions in laboratory animals, including animals with simulated intoxications, have been supplemented and summarized. Product Description popup.authors Abraimova Olha Ye. Maslak Hanna S. Netronina Olha V. Shevtsova Kseniia V. popup.nrat_date 2025-01-26 Close