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Information × Registration Number 0225U001171, (0124U000529) , R & D reports Title X-ray diagnosis of changes in the chemical activity of atoms in human soft tissues at the early stages of the development of pathogenesis. popup.stage_title Експериментальне дослідження тканин при термічному та хімічному впливі. Head Mykhailov Anton I., Доктор фізико-математичних наук Registration Date 26-01-2025 Organization National Technical University "Kharkiv Polytechnic Institute" popup.description1 Development of X-ray diagnostics of the early stages of the pathogenesis of biological tissues based on changes in the electronegativity of atoms and the distribution of nano-impurities in the zone affected by thermal, chemical and radioactive factors. popup.description2  Complex secondary emitters based on Ag, Zr, Nb, Mo, Y and Ge have been developed for measuring scattering spectra on an EDXRF spectrometer; a method for preparing samples for X-ray spectral analysis of blood serum and exudate from gunshot wounds has been developed; sensitivity for determining trace elements at the level of 10-50 ng has been achieved, which corresponds to the level of the most modern research methods. Experimental measurements of the dependence of the ratio of coherent and incoherent scattering peaks were carried out on multicomponent standards and samples with a light matrix; samples of blood serum and exudate from gunshot wounds were studied; the volume of studies was up to 10 combatants per week. An X-ray optical scheme for measuring nanoimpurities in biological tissues using an EDXRF spectrometer has been developed; complex secondary targets Ge/Nb and Ge/Ag have been calculated, designed and manufactured. The limits of detection of nanoimpurities were experimentally determined. Using the latest X-ray optical scheme, the influence of the sample preparation method on the sensitivity of nanoimpurity detection was investigated. It has been experimentally proven that to ensure the required detection limit, optimization of the scheme is not enough for liquid samples: plasma and exudate without sample enrichment (only the main trace elements Ca and K were clearly detected; while hair analysis without enrichment gives satisfactory results. For solid samples, an enrichment method through burning of the organic component was also developed. Thus, using the optimized X-ray optical scheme based on complex secondary targets Ge/Nb and Ge/Ag, and the method of sample preparation for X-ray spectral analysis of blood serum and exudate from gunshot wounds, more than 100 samples of biomaterial were examined. The experimental material was transferred for further research to the "Military Medical Clinical Center of the Northern Region". Product Description popup.authors Baturin Oleksii A. Devizenko Oleksandr Yu. Kushtym Anton V. Nehoduiko Volodymyr V. Sevriukova Viktoriia A. popup.nrat_date 2025-01-26 Close