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Information × Registration Number 0225U001198, (0123U100109) , R & D reports Title Development, standardization and experimental study of the safety and effectiveness of a wound-healing agent containing snail mucin extract (Helix aspersa) popup.stage_title Технолого-аналітичні дослідження Head Hudz Nataliia I., Доктор фармацевтичних наук Registration Date 27-01-2025 Organization Danylo Halytsky Lviv National Medical University popup.description1 The purpose of the work is to develop an experimentally based formulation of the wound-healing product with the snail (Helix aspersa) mucin extract with biocidal activity for reducing antibiotic resistance among the population popup.description2 The compositions and laboratory technology of some hydrophilic creams based on linseed, olive oil, sunflower oil, avocado oil, and pumpkin seed oil, as well as the ready-to-use base Lekobaza, were developed based on experimental technological studies, mathematical calculations of the desired value of the hydrophilic-lipophilic balance of the emulsion system, the microbiological studies on the microbial purity of the developed creams, the biological studies using the chorioallantoic membrane and the wound surface model in rats. The qualitative and quantitative composition of the excipients, particularly cetostearyl alcohol, Tween 20, Tween 80, glycerin, Olivem 1000, phenoxyethanol, and biologically active substances, was scientifically substantiated. Based on numerous studies, it was found that avocado oil-based cream using Tween as an emulsifier provides a significantly better release of the antimicrobial substances from the cream base and thus provides a better pharmacological effect (wound healing). Along with the development of cream formulations, alternative preclinical experimental studies were conducted to assess the irritant effect in the HET-CAM test. Experimental studies showed that the bases of creams with linseed and olive oils do not cause an irritant effect; a cream containing 45% snail mucin extract (Helix aspersa) based on linseed oil showed a weak irritant effect; a cream containing 45% snail mucin extract (Helix aspersa) based on olive oil did not cause an irritant effect. The results obtained confirmed the safety of the correctly developed formulations of the products, which will be taken as the basis for subsequent studies Product Description popup.authors Kuzminov Borys P. Lukasevych Nadiia F. Motyka Olena I. Turkina Vira A. Chemodurova Nataliia Ye. popup.nrat_date 2025-01-27 Close