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Information × Registration Number 0225U001205, (0123U100712) , R & D reports Title To determine the histological and immunohistochemical features of the growth and spread of non-small cell lung cancer to clarify histogenesis. popup.stage_title Вивчити гістологічні особливості росту залозистого раку в альвеолах в центральних і периферичних відділах легені. Head Bolhova Lidiia S., Доктор медичних наук Registration Date 27-01-2025 Organization National Cancer Institute popup.description1 To determine the histogenesis of non-small cell lung cancer by studying histological serial sections using classical dyes, immunohistochemical reagents and molecular genetic studies. popup.description2  The object of the study: patients with lung adenocarcinoma (LAC) macroscopic and histological data. The purpose of scientific research is to determine the histological features of the growth and spread of lung adenocarcinoma in order to clarify histogenesis. Research material and methods. The main clinical and macroscopic data of operative materials and histological studies of 15 patients with lung adenocarcinoma were studied. Histological preparations were prepared according to generally accepted methods and stained with hematoxylin and eosin, of method Papanicolaou. Olympus BX41, microscope were used at magnifications: x200; x400; x1000. The histological type of neoplasm was established according to the International histological classification. The age, sex of patients, number of tumor nodes on the surgical specimen, spread of LС, exophytic growth, damage to lymph nodes (LN) in 15 patients with LC and determined features of histological growth relative to the wall of the bronchus and lung parenchyma were determined. Main conclusions. Histological studies revealed the growth of LAC in the alveoli of all 15 patients in the direction from the basement membrane to their center, where necrosis develops, which confirms the generally recognized characteristic morphogenesis of epithelial (cancerous) tumors. On serial sections, the transition of the basal epithelium of the bronchus into the alveolus, in which the cancerous tumor is growing, is determined, which brings our research closer to determining the source of the development of LAC. To confirm the identified features, additional immunohistochemical studies are needed, which are planned to be performed at the next stage of the SRW implementation. Product Description popup.authors Med Vladyslav V. popup.nrat_date 2025-01-27 Close