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Information × Registration Number 0225U001382, (0122U000871) , R & D reports Title Investigation of baric properties of quantum dots from a multilayer system for biomedical applications using a neural network popup.stage_title Модель формування КТ при дії гідростатичного тиску та ультразвукової хвилі для їх біомедичних застосувань Head Stoliarchuk Ihor D., Доктор фізико-математичних наук Registration Date 30-01-2025 Organization Drohobych Ivan Franko State Pedagogical University popup.description1 The aim of the project is to establish patterns of influence of deformation effects in CT CdSe with multilayer shell on its optical and structural properties for biomedical applications and visualization of elastic fields in the vicinity of CT using artificial neural networks. popup.description2 Based on the method of self-consistent electron-deformation coupling, the deformation effects in the CdSe-core / ZnS/CdS/ZnS-shell quantum dots, which interact with human serum albumin, were investigated. The pressure on the quantum dot surface, which arises due to the electrostatic attraction of human serum albumin molecules, is calculated, depending on the geometric sizes of quantum dot, the average electron concentration and the albumin concentration. The regularities of change of deformation and band structure of the bionanocomplex of multilayer shell quantum dot with human serum albumin at change of geometrical sizes and structure of quantum dot and surface concentration of human serum albumin are established. It is shown that, in contrast to CdSe / human serum albumin bionanocomplexes, the significant deformations arise in the CdSe / ZnS/CdS/ZnS – human serum albumin bionanocomplexes, which can lead to an energy shift of the edge of the conduction band by 40 meV. The model of the semiconductor quantum dot with a multilayer shell and the quantum dot-human serum albumin bionanocomplex, which are contained in a living cell, was constructed. The regularities of changes in deformation of materials of the quantum dot with changes in cell elasticity (comprehensive modulus) at different core radii, thicknesses of individual shell layers, and surface concentration of albumin molecules were investigated. It is shown that the presence of human serum albumin on the surface of the quantum dot significantly increases its sensitivity to pressure caused by the surrounding medium (living cell). Product Description popup.authors Hadzaman Ivan V. Holskyi Vitalii B. Dankiv Olesia O. Kuzyk Oleh V. Peleshchak Ivan R. Peleshchak Roman M. popup.nrat_date 2025-01-30 Close