Search academic texts

Information × Registration Number 0225U001596, (0122U200746) , R & D reports Title Study the patterns of functional and structural brain changes in the clean-up workers of Chornobyl NPP accident in a remote post-accident period and in persons exposed to radiation under different scenarios of exposure in the state of martial law in Ukraine popup.stage_title Проведення нейропсихіатричних, нейрофізіологічних, нейропсихологічних та клініко-радіологічних досліджень для визначення церебральних ефектів після опромінення за різних сценаріїв та та їх відмінностей від хронічної цереброваскулярної патології (хвороби малих судин головного мозку) у неопромінених осіб. Розробка концепції виникнення радіаційно-асоційованого ураження головного мозку та його діагностичних критеріїв. Head Sushko Viktor O., Registration Date 03-02-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 Reveal the patterns of functional and structural effects of irradiation in the brain in the clean-up workers of Chornobyl NPP accident and in persons exposed to radiation under different scenarios of exposure. Determine the role of radiation-associated and stress-induced brain damage in the pathogenesis of functional-structural cerebral effects. Develop the concept of genesis of radiation-associated cerebral effects and innovative radiation cerebral diagnostic criteria for distinguishing radiation effects from cerebrovascular pathology in non-exposed patients. popup.description2  The study object is the peculiarities of neuropsychiatric, neuropsychological, clinical-radiological, and neurophysiological characteristics of 183 people, of whom 131 were the main group individuals irradiated in adulthood (Chornobyl clean-up workers, n = 63), the SSE "Chornobyl NPP" employees (n = 68)) and 52 unirradiated individuals with cerebral small vessel disease. 24 individuals were selected from the SSE "Chornobyl NPP" employees for further statistical analysis to ensure the comparability of the groups according to the main socio-demographic characteristics. The work aims to determine the patterns of functional and structural effects of radiation in the brains of the Chornobyl clean-up workers and those exposed to ionizing radiation under different exposure scenarios. To determine the role of radiation-associated and stress-induced brain damage in the pathogenesis of functional-structural cerebral effects. To develop a concept of the occurrence of radiation-associated cerebral effects and innovative radiation cerebral diagnostic criteria for distinguishing radiation effects from cerebrovascular pathology in unexposed individuals. Research methods: quantified clinical neuropsychiatric, psychodiagnostic, neuropsychological, clinical-radiological, neurophysiological, and statistical. The patterns of functional-structural effects of radiation in the brains of the Chornobyl clean-up workers and those exposed to radiation under different exposure scenarios were identified. The role of brain white matter neurophysiological and structural changes in the pathogenesis of radiation-associated brain damage was assessed. The role of radiation-associated and stress-induced brain damage in the pathogenesis of functional-structural cerebral effects has been determined. The concept of the occurrence of radiation-associated brain damage has been developed. Diagnostic criteria for radiation-associated brain damage using objective diagnostic methods have been developed. Product Description popup.authors Antypchuk Kateryna Yu. Zakomornyi Oleksandr S. Kreinis Heorhii Yu. Kuts Kostiantyn V. Perchuk Iryna V. popup.nrat_date 2025-02-03 Close