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Information × Registration Number 0225U001629, (0124U002096) , R & D reports Title Smart nanotechnologies in the development of new types of mesoporous adsorbents, functional materials and composite systems for medical purposes popup.stage_title Розробка методів синтезу та вивчення фізико-хімічних властивостей нано-композитів на основі високодисперсних оксидів. Вивчення фазових рівноваг у сумішах порошків гідрофільного та гідрофобного кремнеземів. Дослідження особливостей фазових станів речовин у міжчастинкових зазорах мінеральних носіїв. Вивчення відновлювальних/стабілізуючих властивостей екстрактів. Дослідження структурних параметрів цеолітних матеріалів. Head Turov Volodymyr V., д.х.н. Registration Date 04-02-2025 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description1 Development of the scientific foundations of smart nanopharmacology and technologies for the production of medicinal platforms based on multifunctional heterophase carriers, where, under the influence of activating agents, self-assembly of a nanostructured mineral matrix is carried out, in which biologically active substances of chemical, mineral or plant origin intended for introduction into the body are transferred into a cluster state, their delivery to absorption zones, regulated release with simultaneous binding and removal of toxins and metabolic products from the body. The use of smart nanopharmacology for the development of new types of mesoporous adsorbents, the production of composite systems for medical purposes, painkillers and hemostatic drugs. popup.description2 Hydrogel films based on protonated, deprotonated, and glutaraldehyde-crosslinked chitosan and the active substance ornidazole were obtained. It was shown that using different forms of chitosan carrier it is possible to create composites with controlled release of the active substance. The synthesis of nanosized magnetite powders covered with a protective layer of silica with a surface decorated with noble metal nanoparticles was carried out. The samples obtained high values of saturation magnetization, as for nanoparticles, which confirms the potential for the development of such materials for water purification in magnetic separation processes. A method for the synthesis of spherical suprastructures formed by Janus silica particles with surface -NH2 (amino) and -SH (thiol) groups has been developed. A method for controlling the dynamic viscosity of concentrated silica suspensions by adding 1-5 wt% of fatty acid triglycerides to them has been developed, which, under certain mechanical processing methods, leads to an increase in viscosity by 2-3 orders of magnitude. It has been established that this effect is due to the transition of hydrocarbons in the interparticle gaps from a liquid to a solid state at temperatures much higher than the bulk freezing point. The technology for the production of biologically active additives based on structurally modified silicas and medicinal substances of plant origin – ginseng, betulin, succinic acid and natural amber – has been created and improved. Approaches to the creation of complex composite “smart” systems capable of responding to the introduction of mediator substances into their composition by changing their adsorption, rheological or morphological characteristics have been developed. The factory technology for manufacturing a topical hemostatic composition in powder form, which includes nanosized silica and sodium alginate ("Stop-Blood"), has been developed. Product Description popup.authors Barvinchenko Valentyna M. Baresh Oleksandr M. Borysenko Mykola V. Budniak Tetiana M. Herashchenko Ihor I. Holovan Alina P. Hromovyi Taras Yu. Dudarko Oksana A. Zrol Lina V. Klymenko Nataliia Yu. Kozakevych Roman B. Korobeinyk Alina V. Krupska Tetiana V. Kuzema Pavlo O. Lipkovska Nataliia O. Lahuta Iryna V. Laguta Valentin М. Mischanchuk Oleksandr V. Melnyk Inna V. Mykhalovskyi Serhii V. Moshkivska Nadiia M. Novykova Olena А. Petrovsky Roman Р. Polishchuk Liliia M. Postrelko Valentyn M. Siora Iryna V. Sevostianov Stanislav V. Stavynska Oksana M. Stoliarchuk Nataliia V. Terekh Dariia O. Tomina Veronika V. Turans'ka Svitlana P. Tortykh Valentyn A. Fesenko Tetiana V. Tsyba Mykola M. popup.nrat_date 2025-02-04 Close