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Information × Registration Number 0225U001970, (0122U002636) , R & D reports Title Development of multifunctional nanomaterials with controlled properties for biomedical and technical applications. popup.stage_title Створення багатофункціональних наноматеріалів з керованими властивостями для біомедичних та технічних застосувань. Head Svitlana L. Yefimova, Доктор фізико-математичних наукSeminozhenko Volodymyr P., Доктор фізико-математичних наук Registration Date 12-02-2025 Organization Institute for Scintillation Materials of National Academy of Science of Ukraine popup.description1 Development of multifunctional nanomaterials of different composition (oxide nanocrystals containing ions with variable valency, organic supramolecular structures, hybrid materials) with improved optical and antioxidant properties for technical and biomedical applications. popup.description2 Methods were developed and stable colloidal solutions of TiO₂-x, Mn₃O₄, CeO2-x, CeO2-x:Fe³⁺ nanocrystals (NCs) as well as REVO4:Eu3+ (RE=Gd,Y, La) nanocrystals were synthesized. It was established that the ratio of transition and rare-earth metal ions of different valencies (V⁵⁺/V⁴⁺/V³⁺, Ti⁴⁺/Ti³⁺/Ti²⁺, Mn³⁺/Mn²⁺, Ce³⁺/Ce⁴⁺) in the crystal lattice of the synthesized NCs depends on technological approaches used in their synthesis. This provides a promising basis for manipulating the redox properties of the NCs. The possibility of optimizing the antioxidant activity of oxide NCs (in particular, CeO2-x) was demonstrated through the creation of organic-inorganic complexes with synergistic action of organic and inorganic components. A method was developed to evaluate the membranotropic effects of pharmaceutical substances depending on the composition of the drug. This method can be used to optimize the composition of pharmaceuticals to achieve the most effective combinations. For the first time, J-aggregates of cyanine dyes were formed in the nematic liquid crystalline matrix of 5CB, including both the anionic dye TDBC and the cationic dye PIC. This can be used to create luminescent liquid crystalline matrices with high anisotropy of luminescence for photonics and the development of nanolasers. The effect of photo- and physical stabilization of J-aggregates in the liquid crystalline matrix was revealed. Methods for producing perovskite NCs in polymer matrices were proposed, which are simple, cost-effective, and do not require complex equipment. Materials based on perovskite NCs can be used to develop new types of scintillation detectors with fast response times and high light output, meeting the modern needs of scintillation technology. Data on the biological activity of GdVO₄:Eu³⁺ NCs were obtained and systematized. Preclinical studies were conducted to evaluate acute and reproductive toxicity, allergenic and sensitizing activity, as well as chronic toxicity. Product Description popup.authors Yefimova Svitlana L. Aslanov Andrii V. Belenichev Ihor F. Barannik Serhii V. Bespalova Iryna І. Borovyi Ihor A. Bukhtiiarova Nina V. Vashchenko Olha V. Vlasova Iryna D. Viahin Oleh H. Halenin Yevhenii P. Hamidov Mykhailo O. Hrankina Iryna I. Hryhorova Hanna V. Hubenko Kateryna О. Dudetska Halyna V. Domin Oleksandr V. Zelenska Olha V. Zuber Valerii M. Kavok Natalia S. Karpenko Nina О. Kasyan Natalia О. Klochkov Volodymyr K. Kolesnikova Olena V. Lysetskyi Lonhin M. Mitsai Larysa Y. Maksymchuk Pavlo О. Nikitchenko Yurii V. Pisklova Polina V. Paziura Yuliia I. Rebrov Oleksandr L. Rebrova Tatyana P. Ropakova Iryna Yu. Siedykh Olha O. Samoilov Oleksandr M. Seminko Vladyslav V. Sydorenko Olha S. Skrypnyk Tamara V. Sorokin Oleksandr V. Cherhynets Viktor L. popup.nrat_date 2025-02-12 Close