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Information × Registration Number 0225U002067, (0120U000222) , R & D reports Title Patterns of the influence of chemical, natural and physical virus-inactivating agents on biological processes in the virus-cell system popup.stage_title Закономірності впливу хімічних, природних та фізичних вірусінактивуючих агентів на біологічні процеси в системі вірус-клітина Head Zahorodnia Svitlana D., Кандидат біологічних наук Registration Date 18-02-2025 Organization Institute of Microbiology and Virology named after D. K. Zabolotny of the National Academy of Sciences of Ukraine popup.description1 popup.description2  Research report 160 pages, 30 tables, 66 figures, 1 appendix, 45 references. Objects of research - influenza virus type A (H1N1) strain A/FM/1/47, human adenoviruses of 2, 3 and 5 serotypes; herpesviruses: Epstein-Barr virus, herpes simplex virus type 1 (strain US) and type 2 (strain VN). Purpose - to study the development of viral infection under the influence of chemical, natural and physical viral inactivating agents in order to optimize the methods of treatment of viral infections. Research methods: virological, molecular biological, bioinformatic, immunochemical, statistical. Modeling of viral infection in cell culture under the influence of chemical, natural and physical virus-inactivating agents. The peculiarities of antiviral action of silver nanoparticles coated with natural resin, polyhydrated fullerene preparation, newly developed compounds and materials (Tibetan green tea extracts, silver nanoparticles stabilized with various solvents, metal oxide nanoparticles and nanocomposites based on them, nanoplastic) and physical factors of influence were studied. The effect of the experimental materials and substances on different stages of virus reproduction was determined, and the lethal analysis of the role of silver nanoparticles from individual antiviral action to their incorporation into composites and materials was carried out. Based on the data obtained, recommendations were developed on the optimal ways to use them to prevent the spread of viral infections. The determined multifunctional antiviral effect against DNA- and RNA-containing viruses suggests the prospects of introducing innovative technologies, namely nanoparticles and materials from them into the practice of health care and environmental protection. Keywords: adenovirus, herpes simplex virus, influenza virus, green tea extracts, nanostructures, nanoparticles, fullerene, photoactivation Product Description popup.authors Artiukh Liubov O. Baranova Halyna V. Bohdan Mykhailo M. Bokovnia Alona Yu. Holovаnʹ Anna V. Zhuravlova Mariia D. Zaremba Andrii A. Zaremba Polina Yu. Zatovska Tetiana V. Zelena Liubov B. Lychak Oleksandra V. Mukhina Nataliia V. Naumenko Krystyna S. Nyzhenets Anhelina P. Pankivska Yuliia B. Povnytsia Olha Yu. Tkachenko Nina Yu. Shchytinina Hanna S. popup.nrat_date 2025-02-18 Close