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Information × Registration Number 0225U002154, (0122U000326) , R & D reports Title To study the immunoregulatory and neuroprotective properties of trophic factors produced by stem and progenitor cells of different origins popup.stage_title Вивчити імунорегуляторні та нейропротекторні властивості трофічних факторів, які продукуються стовбуровими та прогеніторними клітинами різного походження Head Lisianyi Mykola І., д.мед.н. Registration Date 21-02-2025 Organization The State Institution "Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine" popup.description1 Based on the study of the biological activity of factors produced by stem cells, to create a protocol for obtaining a new drug popup.description2 Report on the GDR: 98 pp., 12 tables, 6 figures, 106 sources. Key words: STEM CELLS, TROPHIC FACTORS, SECRETOME, IMMUNOMODULATION, PROLIFERATION, NEUROPROTECTION, REGENERATION, CRANIAL - BRAIN INJURY.  Secretions obtained from cells of various types of origin and their standardization by protein content. The cell secret exerts a dose-dependent suppressive, suppressive effect on the cytotoxic activity of killer cells in an in vitro test, and dose-dependently affects the proliferative activity of lymphocytes in the blast transformation reaction. The greatest suppressive effect on FHA-stimulated RBTL was found under the action of SGZF, SS, SCM secretion at a dose of 100 μg/ml It was established that the greatest inhibitory effect on the spontaneous production of the superoxide anion radical in the HST test was obtained when using SNZF and SCM at a dose of 100 μg/ml. It was established that SGZF, SCM, as well as SS have in their composition factors that affect the regenerative processes during the experimental wound process in rats. It was established that SGZF, SNZF and SCM have antitumor activity in vivo in experimental C6 glioma in rats. Cell secretomes of different types of origin show multidirectional immunomodulatory activity on immunocompetent cells in in vitro tests and affect regenerative processes and glioma development in the experiment. Product Description popup.authors Bielska Liudmyla M. Klyuchnikova Antonina I Pedachenko Yevhenii H. popup.nrat_date 2025-02-21 Close