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Information × Registration Number 0225U002198, (0124U000083) , R & D reports Title To determine the redox modulation of blood enzymes as markers of the course of breast cancer with adipose tissue dysfunction (code: 2.2.5.459) popup.stage_title Дослідити рівні генерування супероксидних радикалів (СР), активності матриксних металопротеїназ -2 та -9 (ММП-2 та -9), рибонуклеаз (РНКаз) та орнітиндекарбоксилази (ОДК) в периферичній крові хворих на РМЗ. Head Hanusevych Iryna I., Доктор біологічних наук Registration Date 24-02-2025 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description1 To investigate changes in the redox state and enzyme potential of peripheral blood as a result of adipose tissue dysfunction in connection with the course of the tumor process in breast cancer patients. popup.description2  It was found that changes in the redox modulation of enzymes in obesity are associated with the menopausal status of patients with breast cancer: in postmenopausal patients, high levels of platelet gelatinase activity are associated with a deepening of redox imbalance in adipose tissue and blood and low survival. The study of redox indicators of obesity as a significant pro-oxidant factor and the basis for the unfavourable course of breast cancer in the post-productive age expands current fundamental knowledge and is useful for adjusting treatment regimens and improving the effectiveness of therapy. High levels of neutrophil/lymphocyte and platelet/lymphocyte ratios are factors of unfavourable breast cancer course and high risk of mortality, taking into account the content of tumour-associated adipocytes (TAA), but independently of BMI. The use of commonly accepted markers of breast cancer in combination with the assessment of TAA content is appropriate for improving the prognosis of the disease, personalised therapy correction and increasing patient survival. Product Description popup.authors Bubnovskaya Larysa M. Verbynenko Alla V. Halieieva Anastasiia M. Marchuk Yehor V. Netreba Maksym S. Rudavka Valentyna F. Samoylenko Olena A. Tropynina Olena S. popup.nrat_date 2025-02-24 Close