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Information × Registration Number 0225U002227, (0122U001363) , R & D reports Title Experimental justification of portal hypertension surgical treatment method selection in children accorded to molecular, morphological and functional changes in liver popup.stage_title Експериментальне обґрунтування вибору методу хірургічного лікування портальної гіпертензії у дітей в залежності від молекулярних та морфо-функціональних змін печінки Head Levytskyi Anatolii F., Доктор медичних наук Registration Date 25-02-2025 Organization Bogomolets National Medical University popup.description1 The aim of the project is to individualize the portal hypertension surgical treatment efficacy in accordance with cellular and subcellular hepatocytes changes study in experimental model popup.description2  The proposed scientific concept in the form of a justification with the subsequent creation of a stable experimental model of the prehepatic form of portal hypertension in rats by partial portal vein ligation allowed, through a phased study, to improve the understanding of morphological changes at the ultrastructural level that occurred in hepatocytes of the deportalized liver, and to bring the study of functional processes based on changes in the intensity of expression of proteins-markers of apoptosis, autophagy and neoangiogenesis closer to a new view of understanding the processes of liver parenchyma remodeling, which are based on chronic deficiency of portal blood supply. The proposed new scientific concept in the form of perioperative tactics for managing pediatric patients with prehepatic and hepatic forms of portal hypertension, aimed at integrating the combination and sequence of endoscopic and surgical treatment approaches, has important scientific and applied significance in the practical activities of a pediatric surgeon in achieving compliance of medical care for children with portal hypertension with world standards of medical care, their consistency with clinical guidelines, and improving the quality of life of patients by minimizing surgical complications and eliminating threatening manifestations of the disease. Product Description popup.authors popup.nrat_date 2025-02-25 Close