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Information × Registration Number 0225U002229, (0119U003575) , R & D reports Title Optimization of diagnosis, treatment and prophylaxis of the development of degenerative and inflammatory diseases of the organ of vision. popup.stage_title Вивчення ефективності вдосконалених технологій діагностики та патогенетично орієнтованих диференційованих підходів лікування дегенеративних та запальних захворювань органа зору (міопії, кератитів, катаракти, глаукоми, діабетичної ретинопатії, вікової дегенерації макули) Head Venher Liudmyla V., д.мед.н. Registration Date 25-02-2025 Organization Odessa National Medical University popup.description1 popup.description2  116 patients with various forms of AMD and 50 people without ophthalmic pathology were under clinical observation. The peculiarities of the morphometric changes of the retina and choroid in patients with age-related macular degeneration (AMD) according to Swept-Source-optical coherence tomography data, the role of plasticity of the retina in the occurrence of its irreversible damage in AMD were studied. Studied the effects of CFH (rs1061170) and TGFB1 (rs1800469) gene variants on the risk of developing different forms of AMD, it was determined that the frequency of the 1277CC genotype of the CFH gene was significantly increased in patients with AMD. Examination and treatment of 150 patients. Atrophy of the optic nerve was diagnosed in 30 patients out of 36 subjects with neuritis on the background of anterior uveitis 16 of them after 6 months, the others after 12 months of observation. Thickening of the mucosa of the maxillary sinus was noted in all patients with optic neuritis (36 patients) and only in 2.6% of cases - in the absence of complications. The thickness of the diameter of the optic nerve in diseased and healthy eyes of patients with chronic anterior uveitis after disease relapse was determined using computed tomography (CT). Accumulation of fluid in the maxillary cavity was detected in more than a third of patients with uveitis in the presence of concomitant neuritis, and in persons without neuritis - only in 5 patients (4.4%). The results of the study of the subfoveolar thickness of the choroid in 55 patients (67 eyes) with various phenotypic manifestations of age-related macular degeneration according to SS-optical coherence tomography data were obtained. Determination of the expression level of molecular markers of lymphocyte activation CD 5 (marker of autoimmune process), CD 25 (indicator of IL-2 activation), and CD 54 (adhesion marker). Product Description popup.authors Yepisheva Svitlana M. Venher Anna Yu. Venher Liudmyla V. Venher Liudmyla O. Diachkova Zinaida Ye. Konovalova Nataliia V. Tereshchenko Anastasiia A. popup.nrat_date 2025-02-25 Close