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Information × Registration Number 0225U002288, (0121U113839) , R & D reports Title Medical sorbents and nanomaterials in experimental therapy of systemic manifestations of cytostatic disease (2.2.5.446) popup.stage_title Вивчення ефективності комплексного застосування ентеросорбентів і наноматеріалів щодо послаблення інтенсивності побічних реакцій протипухлинної цисплатин-індукованої цитостатичної хвороби у щурів з карциномою Герена Head Sarnatskaya Veronika V., Доктор біологічних наук Registration Date 01-03-2025 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description1 Experimental justification of complex application of carbon sorbents of medical purposes and nanomaterials for diminishing the intensity of antitumor chemotherapy side effects popup.description2 The daily administration of granular activated carbon enterosorbent or the intraperitoneal injection of a combined suspension of carbon particles and nanoceria two hours after cisplatin administration to rats with Guerin tumours, results in a fourfold reduction in tumour volume compared to the effect of the cisplatin alone, and an increase in platelet and erythrocyte counts, haemoglobin concentration and haematocrit. The administration of СeO2&C and enterosorbents will help to protect and restore bone marrow cells, normalise AlAT, AcAT, amylase and alkaline phosphatase, increase total protein and albumin levels, decrease urea concentration and increase LDH and glucose concentrations. In addition, the administration of СeO2&C suspension causes an increase in catalase activity in rat blood haemolysates by an average of 35.5% and a 2.7-fold decrease in the concentration of diene conjugates in blood plasma, while the content of malondialdehyde and the concentration of oxidatively modified proteins do not change significantly. The administration of СeO2&C suspension caused positive changes in the morphological and functional state of the heart, spleen, liver, kidneys and small intestine. It also promoted the destruction of tumour tissue, in which significant foci of necrosis with lymphoid cell infiltration, destroyed blood vessels, increased manifestations of cellular polymorphism, as well as the presence of significant areas of fibrous tissue formed at the site of tumour cell destruction were detected. Biochemical, haematological and cytofluorometric data, as well as the results of morphological and morphometric studies of internal organs and tumour tissues, showed that administration of carbon enterosorbents and a combined СeO2&C suspension is very effective and expedient for reducing the intensity of side effects of cisplatin-induced cytostatic disease in rats with Guerin's carcinoma.  Product Description popup.authors Herashchenko Bohdan I. Klymchuk Dmytro O Korneeva Liudmyla M. Korotych Valentyna H. Paziuk Liubov M. Sydorenko Oleksii S. popup.nrat_date 2025-03-01 Close