Search academic texts

Information × Registration Number 0225U002416, (0122U001488) , R & D reports Title To investigate vascular endothelium growth factor in vitreous in order to increase the effectiveness of the treatment of patients with diabetic retinopathy popup.stage_title Дослідити фактор росту ендотелію судин в скловидному тілі з метою підвищення ефективності лікування хворих на діабетичну ретинопатію Head Umanets Mykola M., Доктор медичних наук Registration Date 10-03-2025 Organization VP Filatov Institute of Ophthalmology and Tissue Therapy of the National Academy of Medical Sciences of Ukraine popup.description1 The aim is: to investigate the relationship between vascular endothelium growth factors in vitreous and proliferative process in patients with diabetic retinopathy for justification a differentiated doses of aflibercept (1 mg and 2 mg) to increase the effectiveness of the treatment of patients with diabetic retinopathy popup.description2  The study is devoted to the diagnostic and treatment optimization of complicated forms of PDR by studying the VEGF level in the vitreous body of patients with PDR, its dependence on clinical indicators and eye interventions before vitrectomy, changes of the VEGF level in the vitreous body after intravitreal injection of different doses of aflibercept. Also the morphology and ultrastructure of epiretinal membranes, their changes after intravitreal injection of different doses of aflibercept was investigated, and efficacy of intravitreal injection of aflibercept in a dose 1,0 mg and 2,0 mg in different terms before vitrectomy was compared. It was found that the level of VEGF in the vitreous body of patients with PDR does not depend on the type and duration of diabetes, pseudophakia or previously performed panretinal laser coagulation, and was 757.7 pg/ml. The level of VEGF depends on the degree of the proliferative process in the eye: in cases of advanced epiretinal membranes is 997.0 pg/l in comparison with 224.9 pg/l in moderate epiretinal membranes, and significantly decreases almost 2 times after intravitreal aflibercept injection, regardless of the dose (1.0 or 2.0 mg) and the period after administration (3 or 5 days). A number of differentiated blood vessels embedded in mature fibrous tissue were found in samples of native epiretinal membrane. After intravitreal aflibercept injection, regardless of the drug dose, complete obliteration of newly formed microvessels is observed on the 5th day. According to the data of electron microscopy, on the 5th day, the destruction in the cellular and fibrous structures of the epiretinal membranes were revealed. That justifies the terms of the safest surgical intervention with the removal of epiretinal membranes.The modified foveo-sparing technique of ILM peeling in idiopathic macular hole surgery was developed after evaluation of the shortcomings of the existing methods of ILM peeling. Product Description popup.authors Veselova-Liubimova Iryna S. Dovhan Inna P. Rozanova Zoia A. Samoilenko Liudmyla I. Khramenko Nataliia I. popup.nrat_date 2025-03-10 Close