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Information × Registration Number 0225U002420, (0122U001487) , R & D reports Title Investigate the role of gas transmitters of hydrogen sulfide and nitric oxide in the glaucoma process and the influence on the mechanisms of its development of the blocker angiotensin - converting enzyme zofenopril in the conditions of disease modeling popup.stage_title Дослідити роль газотрансмітерів гідроген сульфіда та оксиду азоту в глаукомному процесі та вплив на механізми його розвитку блокатору ангіотензин – перетворюючого ферменту зофенопріла в умовах моделювання захворювання Head Mykheitseva Iryna M., Доктор біологічних наук Registration Date 10-03-2025 Organization State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine" popup.description1 Іnvestigate the involvement and interaction of gas signaling molecules of hydrogen sulfide (H2S) and nitric oxide (NO) in the mechanisms of oxidative and nitrosative stress on the pathogenesis of primary glaucoma in modeling the disease in rabbits and to study the effect of angiotensin-converting enzyme blocker the course of the pathological process popup.description2  Object of research – indicators of intraocular pressure, hydrodynamics, hemodynamics, oxidative stress and nitric oxide metabolism, antioxidant system and activity of constitutive NO-synthase, hydrogen sulfide content in tissues of the drainage zone of the eye, retina and optic nerve of animals in modeling adrenaline-induced glaucoma (AIG) under the influence of zofenopril. The aim is to investigate the participation and interaction of the gas signaling molecules hydrogen sulfide (H2S) and nitric oxide (NO) in the mechanisms of pathogenesis of primary glaucoma in modeling the disease in rabbits and to study the effect of the angiotensin-converting enzyme (ACE) blocker zofenopril as a source of H2S on the metabolism and course of the pathological process. Research methods and equipment - pathophysiological, biochemical, ophthalmological, statistical analysis, spectrophotometer SF-26, Spekol 11, 21, 210, pH meter "Seven Easy", laboratory scales FEN - 1000, torsion scales BT - 500, TW-2, T-4, thermostat VEB NBE, UH-8, centrifuge "MPW-310". Results and novelty. The results of an experimental study on a disease model have established for the first time the role of the gaseous transmitter hydrogen sulfide (H2S) in the pathogenesis of primary glaucoma, and have also revealed for the first time the effect of H2S on the metabolism of another gaseous signaling molecule - nitric oxide in glaucoma target tissues of the eye (drainage zone, retina, optic nerve). The positive effect of the ACE inhibitor zofenopril, as a potential donor of physiological doses of H2S, on the hydro- and hemodynamics of the eye in experimental glaucoma, as well as on the pathogenetic links of metabolism, has been shown for the first time. Product Description popup.authors Yendrzheevska Tetiana V. Alobisi Maiar M. Kolomiichuk Serhii H. Kuznetsov Maksym K. Kucherenko Svitlana M. Siroshtanenko Tetiana I. Storozhuk Nataliia V. Khramenko Nataliia I. popup.nrat_date 2025-03-10 Close