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Information × Registration Number 0225U002430, (0122U002521) , R & D reports Title The effect of metformin on the development of male offspring in the juvenile-induced metabolic syndrome in the paternal generation in an experiment on rats. popup.stage_title Дослідження цитохром Р450-залежних та гормонопосередкованих процесів в механізмах Дослідження цитохром Р450-залежних та гормонопосередкованих процесів в механізмах віддаленого впливу на репродуктивну функцію потомства F1 самців щурів за умов застосування метформіну у батьківського покоління за метаболічного синдрому, сформованого в ювенільний період розвитку. Head Kovalenko Valentyna M., д.б.н. Registration Date 11-03-2025 Organization Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine popup.description1 To investigate the safety / efficacy and mechanisms of action of metformin on embryonic, postnatal development and reproductive function of F1 offspring from male rats in which the metabolic syndrome developed at juvenile age. popup.description2  The use of metformin against the background of MS induction in juvenile male rats in the late period of development worsened the morphological picture of the testes, the level of embryolethality of their offspring. In the offspring (F1 generation), upon administration of metformin, the male:female ratio decreased, regardless of sex, and the anogenital distance increased, which indicates a violation of reproductive function. No transgenerational effect of MS or metformin on other studied parameters was detected. Insulin resistance in male rats with juvenile PTSD indicates a relationship between PTSD and MS. The administration of fluoxetine led to a decrease in the number of spermatozoa and fertilization ability, and in the offspring, regardless of sex, the anogenital index decreased. Fluoxetine also contributed to an increase in general anxiety and a decrease in social interaction. Product Description popup.authors Bondarenko Larysa B. Shaiakhmetova Hanna M. popup.nrat_date 2025-03-11 Close