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Registration Number

0225U002439, (0123U101051) , R & D reports

Title

To study the features of regenerative processes in the brain and nerve trunk during the modulation of the accumulation and differentiation of mesenchymal stem cells

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Вивчити особливості відновлювальних процесів у головному мозку та нервовому стовбурі при модуляції накопичення та диференціювання мезенхімальних стовбурових клітин

Head

Hrabovyi Oleksandr M., д.мед.н.

Registration Date

11-03-2025

Organization

Bogomolets National Medical University

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To increase the degree of recovery of brain and peripheral nerve structures by increasing the number of progenitor cells at the site of damage and modulating their differentiation into organ-specific elements

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 The work is devoted to the creating of new methods of promoting functional recovery after damage to the nervous system, especially after hemorrhagic stroke and complete transection of a peripheral nerve. In a fundamental study, new patterns of scar tissue development in a damaged nerve were established. The application of a high dose of dexamethasone and stimulation of the pool of mesenchymal stem cells, inhibition of the formation of scar tissue in the regenerative neuroma was proven, leading to successful regeneration of the damaged nerve. A modifying effect on the glial scar formation around a intracerebral hemorrhage, the relationship of reactive astrogliosis with the severity of a stroke and the immunophenotypic nature of the accumulated mesenchymal cells in the brain have been proven. We consider the developed scheme of a combination of high doses of glucocorticoids with granulocyte-stimulating factor to be an important area of work, which ensures the accumulation of mesenchymal cells in the damaged tissues of the peripheral nerve and around hematoma in brain after a hemorrhagic stroke, which is evidence of the modulating effect of the developed combination in stimulating recovery processes. The obtained new data will improve the functional results after the reconstructive and restorative treatment of injured nerve trunks, and significantly improve the functional recovery after a stroke. GCSF has been shown to potentiate the accumulation of cells that express vimentae in sites of glial scar formation in hemorrhagic stroke.

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2025-03-11