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Information × Registration Number 0225U002739, (0122U001318) , R & D reports Title The concept for an alternative application of antibiotics strategy to provide the effective barrier function of the intestines of productive animals popup.stage_title Концепція альтернативної використанню антибіотиків стратегії для забезпечення ефективної бар’єрної функції кишечника продуктивних тварин Head Nedzvetskyi Viktor S., Доктор біологічних наук Registration Date 01-04-2025 Organization Dnipro state agrarian and economic university popup.description1 Development of an innovative comprehensive strategy for alternative use of antibiotics to maintain intestinal health in weaned piglets popup.description2 Studying the effectiveness of alternative strategies to antibiotic use to maintain gut health in productive animals will contribute to livestock productivity and reduce antibiotic resistance. The idea of ​​the project is that monoglycerides exhibit antimicrobial activity, primarily against enteropathogenic bacteria; - monoglycerides are included in the metabolism of intestinal epithelial cells; - muramylpeptide modulates intestinal immune resistance; - postbiotics modulate the cellular response of epithelial cells and intestinal barrier function. Considering the fact that all these effects are aimed at supporting the central functions of the intestinal system, the combined action of these compounds may inhibit the proliferation of enteropathogens and the development of antibiotic resistance by supporting barrier function. Furthermore, this can be transformed into a sustainable, environmentally friendly approach that can be implemented in antibiotic-free livestock farming to produce safe and high-quality meat. The aim of the work is to develop a concept for an alternative strategy to the use of antibiotics to ensure effective barrier function of the intestines of productive animals. The object of research is biochemical, molecular and cellular processes that provide barrier and immune function in the intestines of animals and may be a promising direction in the fight against the growth of antibiotic resistance. The main idea of ​​the research was to study biological mechanisms to develop innovative strategies and alternatives to antibiotics to ensure productivity in livestock and poultry farming. Product Description popup.authors Alifonova Kira V. Andriievskyi Hryhorii V. Havrysh Anatolii S. Holda Anton A. Dolina Yuliia V. Kokariev Andrii V. Masiuk Dmytro M. Masiuk Oleksandr M. Matsiuk Valeriia O. Neverkovets Nataliia Yu. Novitskyi Roman O. Romanenko Eduard R. Sytnyk Nataliia M. Tamchuk Liliia M. Tykhomyrov Artem O. Farimets Zlata V. Khomenko Kateryna V. Chebanova Karyna O. Yakushkina Maryna I. popup.nrat_date 2025-04-01 Close