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Information × Registration Number 0225U002771, (0124U001303) , R & D reports Title Innovative nanobiotechnology to accelerate the post-traumatic recovery of the musculoskeletal system functional activity popup.stage_title Механокінетичні дослідження функціонального стану скелетних м’язів щурів на тлі їх атрофічного переродження внаслідок тривалого знерухомлення після механічної травми та дії водорозчинних С60 фулеренів залежно від дози і способу введення. Head Nozdrenko Dmytro М., Доктор біологічних наук Registration Date 02-04-2025 Organization Taras Shevchenko National University of Kyiv popup.description1 The purpose of the work: the development of the safe and effective technology for using water-soluble C60 fullerenes to reduce the consequences of pathological processes in skeletal muscles, caused by trauma and their subsequent atrophy, due to the long-term immobilization and ischemia, as well as the time required to fully restore the damaged skeletal muscle functioning. popup.description2 The mechanokinetic parameters of the contraction of the soleus muscle of rats against the background of their atrophic degeneration due to prolonged immobilization after mechanical injury were studied. The parameters of muscle contraction (maximum contraction force and muscle force impulse) were determined on the 15th, 30th and 45th day after the initiation of atrophy using strain gauges. A C60 fullerene aqueous solution (C60FAS; daily oral administration at a dose of 1 mg/kg throughout the experiment) was used as a therapeutic nanoagent. In all tests, the administration of C60FAS recorded an increase in the maximum contraction force and muscle force impulse by 29–49±2 % and 21–37±2 %, respectively, compared with the atrophy group. Nerve conduction was also assessed during stimulation of the soleus muscle of rats after prolonged immobilization of the hind limbs. The analysis of the mechanokinetic parameters of muscle contraction was performed on the 45th day after the initiation of atrophy. It was found that when the delay in the onset of muscle contraction caused by 1 and 2 Hz stimulations was detected, its sharp increase was detected from 98±6 ms in the control to 443±8 and 487±7 ms after the initiation of atrophy, respectively. In all tests conducted with therapeutic administration of C60FAS, an increase in nerve conduction was recorded by 31±2 % and 36±2 % at 1 and 2 Hz stimulation, respectively, relative to the atrophy group. This indicates the presence of compensatory activation of the endogenous antioxidant system by C60 fullerenes in the process of dystrophic changes caused by long-term immobilization. Thus, the results obtained indicate the prospects for the use of water-soluble C60 fullerenes, capable of reducing/correcting pathological conditions of skeletal muscles that occur during their atrophy after mechanical injury.  Product Description popup.authors Bohutska Kateryna I. Pampukha Ihor V. Prylutskyi Yurii I. popup.nrat_date 2025-04-02 Close