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Information × Registration Number 0225U002946, (0124U001027) , R & D reports Title The search for microorganisms producing new promising antimicrobial compounds for the prevention and treatment of combat injuries in conditions of purulent complications popup.stage_title Пошук і відбір ізолятів, створення робочої колекції штамів зі здатністю до продукції бактеріоцинів Head Merlich Andrii G., Кандидат біологічних наук Registration Date 22-04-2025 Organization Odesa I.I. Mechnikov National University popup.description1 The aim of the project is to search among representatives of extremophilic marine microbiota of the sea and hypersaline water bodies for promising producers of new bacteriocins with antimicrobial activity against pathogens of purulent infections, which can be used to treat the wounded with combat trauma popup.description2  At the first stage of the project, 6 water samples and 38 aquatic organisms from the Black Sea were taken and processed. The presence of a small number of lactobacteria in water and mussels in the winter period was detected. The results of metagenomic analysis showed the predominance of microorganisms of the ancient group of archaea (56.5%) in the water of the hypersaline reservoir of the Kuyalnytskyi estuary, which confirms their adaptation to hypersaline conditions. In total, 300 new isolates of lactobacteria were isolated from water and marine inhabitants of the Odessa Bay of the Black Sea, among which for the first time in the world active producers of bacteriocins of Black Sea origin were found, of which there were three strains (1% of the total number). Producers of bacteriocin-like compounds (8 strains of active antagonists) were also found among the collection of marine bacillus isolates obtained from deep-sea samples of the Black Sea, collected during previous expeditions. The distribution of the phenomenon of bacteriocinogeny among microorganisms of the Black Sea was studied for the first time and its presence was shown in low number of lactobacteria from Black Sea water and algae, as well as in aerobic spore-forming bacteria from soil sediments. From the three new strains of marine lactobacteria and eight strains of bacilli that are capable of producing bacteriocins, a working collection was created, which will be used at the next stages of the project to produce bacteriocins for their detailed study and development of new effective pharmaceuticals based on them for the prevention and treatment of combat injuries at conditions of purulent complications. Product Description popup.authors Korotaieva Nadiia V. Loboda Mariia I. Merlich Andrii H. Subota Viktoriia V. Tytarenko Nadiia V. Shtenikov Mykola D. popup.nrat_date 2025-04-22 Close