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Information × Registration Number 0225U002977, (0122U001615) , R & D reports Title Functional-oriented design of new azoles - biologically active substances and analytical reagents popup.stage_title Молекулярний дизайн азин 4-азолідонових коньюгатів Фармакологічний скринінг отриманих сполук. Нові аналітичні форми азолів з іонами Os(IV), Rh(III), Mn(II), Cd(II). Head Matiichuk Vasyl S., д.х.н. Registration Date 28-04-2025 Organization Ivan Franko National University of Lviv popup.description1 The aim of the project is a comprehensive study of new azoles: synthesis, pharmacological screening in order to identify leading compounds promising for the development of new drugs, research of optical and electrochemical properties, establishing optimal conditions for complexation with metal ions, development of methods for determining biologically active azoles and their complex compounds. popup.description2  A series of new thiazolo[4,5-b]pyridine-2-ones was synthesized and their anti-inflammatory activity was studied. Synthesis of new triazolothiadiazines and evaluation of their antimicrobial activity was carried out. The proposed synthetic protocols made it possible to design a variety of pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines with significant chemical novelty. The antimicrobial activity of the obtained compounds was evaluated. Effective approaches for the synthesis of 3-furan-2-yl-2-(4-furan/thiophene-2-ylthiazol-2-yl)acrylonitrile derivatives have been proposed. The synthesized compounds are proposed as promising structures for the development of antitumor drugs. Using the Wilgerodt-Kindler reaction of arylfuran-2-carbaldehydes with sulfur and arylpiperazines, 1-aryl-4-[(5-aryl-2-furyl)carbonothioyl]piperazine and a number of new 2-(1H-benzimidazol-2-yl)- and 2-benzthiazol-2-yl-3-(5-arylfuran-2-yl)acrylonitriles were obtained. The biological activity of these compounds was investigated. New azole derivatives were proposed as spectrophotometric and voltammetric reagents for the determination of Pd(ΙΙ), Co(II), Ni(II), Cu(II) and Cd(II). The extraction of Ni(II) and Co(II) complexes from 1-(1-methyl-1H-pyrazol-3-yl-azo)-naphthalene-2-ol with different types of organic solvents was investigated. The optimal conditions for the extraction of the complexes were established and a sensitive method for the extraction-photometric determination of Ni(II) (LOD = 2.1 ng/ml) was developed. In the case of the system Co(II) - 1-(1-methyl-1H-pyrazol-3-yl-azo)-naphthalen-2-ol, it was found that for all types of extractants studied in the organic phase Product Description popup.authors Barabash Oksana V. Horak Yurii I. Drapak Iryna V. Kaminskyi Danylo V. Lytvyn Roman Z. Milian Volodymyr V. Martiak Roman L. Matiichuk Vasyl S. Myrko Iryna I. Oleksiv Lesia V. Ostapiuk Mariia-Sofiia Yu. Ostapiuk Yurii V. Patsai Ihor O. Rydchuk Petro V. Tymoshuk Oleksandr S. Tselevych Mariia V. Chaban Taras I. Shuminskyi Stepan Ye. popup.nrat_date 2025-04-28 Close