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Information × Registration Number 0225U002998, (0124U001470) , R & D reports Title Chemo-, regio- and stereoselective reactions for targeted synthesis of biologically active compounds popup.stage_title Розробка синтетичних підходів до створення нових біологічно активних сполук. Head Mykhailiuk Pavlo K., Доктор хімічних наук Registration Date 29-04-2025 Organization Taras Shevchenko National University of Kyiv popup.description1 Investigate the fundamental problem of chemo-, regio- and stereoselectivity of organic reactions, which will allow open the way to the controlled synthesis of new biologically active compounds for the needs of medical chemistry, agrochemistry, etc. popup.description2 The most likely routes for the controlled synthesis of new biologically active compounds were selected based on a literature review and small-scale test reactions. Thus, we developed a new chemical reagent for accessing methyl sulfones. We found a synthetic approach to the construction of oxetane-containing amide bioisosteres that relies on the readily available oxetane-3-one. We found a synthetic approach to small molecules containing a trifluoromethyl-cyclobutyl moiety by the interaction of sulfur tetrafluoride with cyclobutylcarboxylic acids. We recently developed an efficient photochemical protocol for the synthesis of alkyl-substituted bicyclo-[1.1.1]pentane iodides, and now we have continued our research, expanding the scope of its application. Product Description popup.authors Yehorova Tetiana V. Kysil Аndrii І. popup.nrat_date 2025-04-29 Close